Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NMDA receptor antagonists as analgesics: focus on the NR2B subtype
Autore:
Chizh, BA; Headley, PM; Tzschentke, TM;
Indirizzi:
Grunenthal GMBH Res & Dev, Dept Pharmacol, D-52078 Aachen, Germany Grunenthal GMBH Res & Dev Aachen Germany D-52078 D-52078 Aachen, Germany Univ Bristol, Dept Physiol, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Bristol BS8 1TD, Avon, England
Titolo Testata:
TRENDS IN PHARMACOLOGICAL SCIENCES
fascicolo: 12, volume: 22, anno: 2001,
pagine: 636 - 642
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-ASPARTATE RECEPTOR; CULTURED CORTICAL-NEURONS; INDUCED PLACE PREFERENCE; RAT SPINAL-CORD; SELECTIVE ANTAGONIST; PHENCYCLIDINE-LIKE; RHESUS-MONKEYS; DORSAL HORN; IN-VITRO; IFENPRODIL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Chizh, BA GlaxoSmithKline, Addenbrookes Ctr Clin Invest, Clin Res Unit, Hills Rd, Cambridge CB2 2GG, England GlaxoSmithKline Hills Rd Cambridge England CB2 2GG 2GG, England
Citazione:
B.A. Chizh et al., "NMDA receptor antagonists as analgesics: focus on the NR2B subtype", TRENDS PHAR, 22(12), 2001, pp. 636-642

Abstract

Ifenprodil and a group of related compounds are selective antagonists of NR2B-containing NMDA receptors. These compounds are antinociceptive in a variety of preclinical pain models and have a much lower side-effect profile compared with other NMDA receptor antagonists. It remains unclear whether the improved safety of these compounds is due to their subtype selectivity orto a unique mode of inhibition of the receptor. Human trials have so far confirmed the good tolerability of these subtype-selective NMDA receptor antagonists; however, whether they are as effective as other NMDA receptor antagonists in pain patients remains to be demonstrated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:34:52