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Titolo:
Neuroprotective peptide drug delivery and development: potential new therapeutics
Autore:
Gozes, I;
Indirizzi:
Tel Aviv Univ, Sackler Sch Med, Dept Clin Biochem, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 iochem, IL-69978 Tel Aviv, Israel
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 12, volume: 24, anno: 2001,
pagine: 700 - 705
SICI:
0166-2236(200112)24:12<700:NPDDAD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; BLOOD-BRAIN-BARRIER; DEPENDENT NEUROTROPHIC FACTOR; FEMTOMOLAR-ACTING PEPTIDES; CEREBRAL-ARTERY OCCLUSION; FATTY NEUROPEPTIDE; RAT; NEURONS; VIP; VASOPRESSIN;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Gozes, I Tel Aviv Univ, Sackler Sch Med, Dept Clin Biochem, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 L-69978 Tel Aviv, Israel
Citazione:
I. Gozes, "Neuroprotective peptide drug delivery and development: potential new therapeutics", TRENDS NEUR, 24(12), 2001, pp. 700-705

Abstract

Alzheimer's disease and related neurodegenerative disorders are prevalent among the elderly and might be considered as the plague of the 21 st century. It is thus imperative to find cures for these conditions. The use of nerve growth factor proteins as neuroprotective therapeutics is limited by their hindered mobility through the blood-brain barrier. Peptides provide an attractive alternative. However, do peptide derivatives retain the activity of the entire protein? Are they stable? Would peptides cross the blood-brain barrier and what are the potential side effects? Examples are put forth to strengthen our opinion that peptides are important candidates for future drug development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:40:20