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Titolo:
Polycomb-group genes as regulators of mammalian lymphopoiesis
Autore:
Raaphorst, FM; Otte, AP; Meijer, CJLM;
Indirizzi:
Free Univ Amsterdam, Dept Pathol, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 HV terdam, Netherlands Free Univ Amsterdam, Bioctr, Swammerdam Inst Life Sci, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 HV terdam, Netherlands
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 12, volume: 22, anno: 2001,
pagine: 682 - 690
SICI:
1471-4906(200112)22:12<682:PGAROM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOME-BINDING-SITES; TRANSCRIPTION FACTOR YY1; GROUP PROTEIN COMPLEX; HOX HOMEOBOX GENES; EXTRA SEX COMBS; B-CELL; DROSOPHILA-MELANOGASTER; POLYHOMEOTIC GENE; ZINC-FINGER; POLYCOMB-M33-DEFICIENT MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Raaphorst, FM Free Univ Amsterdam, Dept Pathol, De Boelelaan 1117, NL-1081HV Amsterdam,Netherlands Free Univ Amsterdam De Boelelaan 1117 Amsterdam Netherlands NL-1081 HV
Citazione:
F.M. Raaphorst et al., "Polycomb-group genes as regulators of mammalian lymphopoiesis", TRENDS IMMU, 22(12), 2001, pp. 682-690

Abstract

Polycomb proteins form DNA-binding protein complexes with gene-suppressingactivity. They maintain cell identity but, also, contribute to the regulation of cell proliferation. Mice with mutated Polycomb-group genes exhibit various hematological disorders, ranging from the loss of mature B and T cells to development of lymphomas. Lymphopoiesis in humans is associated with characteristic expression patterns of Polycomb-group genes in defined lymphocyte populations. Collectively, these results indicate that Polycomb-groupgenes encode novel gene regulators involved in the differentiation of lymphocytes. The underlying mechanism is related, most probably, to gene silencing by chromatin modification, and might affect proliferative behavior and account for the irreversibility of lineage choice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:35:05