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Titolo:
Atherosclerosis as an autoimmune disease: an update
Autore:
Wick, G; Perschinka, H; Millonig, G;
Indirizzi:
Austrian Acad Sci, Inst Biomed Aging Res, A-6020 Innsbruck, Austria Austrian Acad Sci Innsbruck Austria A-6020 es, A-6020 Innsbruck, Austria Innsbruck Univ, Inst Pathophysiol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 ysiol, A-6020 Innsbruck, Austria
Titolo Testata:
TRENDS IN IMMUNOLOGY
fascicolo: 12, volume: 22, anno: 2001,
pagine: 665 - 669
SICI:
1471-4906(200112)22:12<665:AAAADA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK-PROTEIN; ENDOTHELIAL-CELLS; SERUM ANTIBODIES; CAROTID ATHEROSCLEROSIS; MONONUCLEAR-CELLS; LYMPHOID-TISSUE; EXPRESSION; IMMUNIZATION; LESIONS; HSP60;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Wick, G Austrian Acad Sci, Inst Biomed Aging Res, Rennweg 10, A-6020 Innsbruck, Austria Austrian Acad Sci Rennweg 10 Innsbruck Austria A-6020 ck, Austria
Citazione:
G. Wick et al., "Atherosclerosis as an autoimmune disease: an update", TRENDS IMMU, 22(12), 2001, pp. 665-669

Abstract

Immunoinflammatory processes are discussed increasingly as possible pathogenic factors for the development of atherosclerosis. Here, we summarize thedata on which we have built our immunological hypothesis of atherogenesis. This concept is based on the observation that almost all humans have cellular and humoral immune reactions against microbial heat-shock protein 60 (HSP60). Because a high degree of antigenic homology exists between microbial(bacterial and parasitic) and human HSP60, the 'cost' of immunity to microbes might be the danger of cross-reactivity with human HSP60 expressed by the endothelial cells of stressed arteries. Genuine autoimmunity against altered autologous HSP60 might trigger this process also.

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Documento generato il 06/04/20 alle ore 01:33:44