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Titolo:
SH2 domains, interaction modules and cellular wiring
Autore:
Pawson, T; Gish, GD; Nash, P;
Indirizzi:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Programme Mol Biol & Canc, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Canc, Toronto, ON M5G 1X5, Canada Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5S 1A8, Canada UnivToronto Toronto ON Canada M5S 1A8 obiol, Toronto, ON M5S 1A8, Canada
Titolo Testata:
TRENDS IN CELL BIOLOGY
fascicolo: 12, volume: 11, anno: 2001,
pagine: 504 - 511
SICI:
0962-8924(200112)11:12<504:SDIMAC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-PROTEIN INTERACTIONS; RECEPTOR TYROSINE KINASES; CRYSTAL-STRUCTURE; BINDING-SITE; SIGNAL-TRANSDUCTION; NEGATIVE REGULATOR; PHOSPHOLIPASE-C; FHA DOMAIN; RECOGNITION; SRC;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Pawson, T Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Programme Mol Biol & Canc, 600 Univ Ave, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp 600 Univ Ave Toronto ON Canada M5G 1X5 1X5, Canada
Citazione:
T. Pawson et al., "SH2 domains, interaction modules and cellular wiring", TR CELL BIO, 11(12), 2001, pp. 504-511

Abstract

SH2 domains serve as the prototype for a growing family of protein-interaction modules, characteristic of polypeptides involved in transmitting signals from external and internal cues. The specific interactions of proteins with one another, and with other cellular components such as phospholipids and nucleic acids, provide a very general device to organize cellular behavior. We discuss the idea that rewiring of the cell's interaction network by pathogenic microorganisms and mutant cellular proteins contributes to dysregulation of cell signaling and thus to disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 11:34:38