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Titolo:
L-ephedrine-induced neuro degeneration in the parietal cortex and thalamusof the rat is dependent on hyperthermia and can be altered by the process of in vivo brain microdialysis
Autore:
Bowyer, JF; Hopkins, KJ; Jakab, R; Ferguson, SA;
Indirizzi:
US FDA, Div Neurotoxicol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA USFDA Jefferson AR USA 72079 tl Ctr Toxicol Res, Jefferson, AR 72079 USA
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1-3, volume: 125, anno: 2001,
pagine: 151 - 166
SICI:
0378-4274(200112)125:1-3<151:LNDITP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; STRIATAL DOPAMINE; METHAMPHETAMINE NEUROTOXICITY; D-AMPHETAMINE; NEUROTROPHIC FACTORS; GLUTAMATE; INJURY; USERS; ADDICTION; CAFFEINE;
Keywords:
neurotoxicity; ephedrine; amphetamine; cortex; thalamus; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Bowyer, JF US FDA, Div Neurotoxicol, Natl Ctr Toxicol Res, HFT-132, Jefferson, AR 72079 USA US FDA HFT-132 Jefferson AR USA 72079 , Jefferson, AR 72079 USA
Citazione:
J.F. Bowyer et al., "L-ephedrine-induced neuro degeneration in the parietal cortex and thalamusof the rat is dependent on hyperthermia and can be altered by the process of in vivo brain microdialysis", TOX LETT, 125(1-3), 2001, pp. 151-166

Abstract

Multiple doses of the dietary supplement L-ephedrine can cause severe hyperthermia, and modest dopamine depletions in the rat brain. Since D-amphetamine treatment can result in neurodegeneration, the potential of L-ephedrineto produce similar types of degeneration was investigated. Adult male rats, some implanted in the caudate/putamen (CPu) for microdialysis, were givenfour doses of 25 mg/kg L-ephedrine or 5 mg/kg D-amphetamine (2 h between doses) at an ambient temperature of 23 degreesC. L-ephedrine-induced degeneration in the forebrain was dependent on the degree of hyperthermia. Layer IV of the parietal cortex was the most Sensitive to L-ephedrine treatment with peak body temperatures of at most 40.0 degreesC necessary to produce degeneration. Extensive neurodegeneration in the parietal cortex after L-ephedrine treatment was as pronounced as that previously described for D-amphetamine treatment and also occurred in the intralaminar, ventromedial and ventrolateral thalamic nuclei in rats with severe hyperthermia (peak body temperatures>41.0 degreesC). The neurodegeneration induced by L-ephedrine may have resulted in part from excitotoxic mechanisms involving the indirect pathways of the basal ganglia and related areas. No differences were observed between microdialysis and non-implanted rats with respect to degree of tyrosine hydroxylase (TH) loss in the CPu after either D-amphetamine or L-ephedrine treatment. However, neuro degeneration resulting from D-amphetamine andL-ephedrine was reduced in the microdialysis animals in the hemisphere ipsilateral to the probe, which raises concerns when using the technique of invivo microdialysis to evaluate neurodegeneration. The results of this study, in conjunction with human clinical evaluation of ephedrine neurotoxicity, indicate that regionally specific damage may occur in the cortex of some humans exposed to ephedrine in the absence of stroke or hemorrhage. (C) 2001 Published by Elsevier Science Ireland Ltd.

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Documento generato il 28/01/20 alle ore 20:59:15