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Titolo:
Oral cocaine produces dose-related hepatotoxicity in male mice
Autore:
Labib, R; Turkall, R; Abdel-Rahman, MS;
Indirizzi:
Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Physiol & Pharmacol, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 acol, Newark, NJ 07103 USA Univ Med & Dent New Jersey, Sch Hlth Related Profess, Dept Clin Lab Sci, Newark, NJ 07107 USA Univ Med & Dent New Jersey Newark NJ USA 07107 Sci, Newark, NJ 07107 USA
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1-3, volume: 125, anno: 2001,
pagine: 29 - 37
SICI:
0378-4274(200112)125:1-3<29:OCPDHI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT DEFENSE; RAT-LIVER; MEDIATED HEPATOTOXICITY; HEPATOCYTE CULTURES; GLUTATHIONE; ETHANOL; MITOCHONDRIA; CYTOTOXICITY; EXPRESSION; MECHANISMS;
Keywords:
oxidative stress; ALT; AST; antioxidants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Abdel-Rahman, MS Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Physiol & Pharmacol, 185 S Orange Ave,Room I-655, Newark, NJ 07103 USA Univ Med& Dent New Jersey 185 S Orange Ave,Room I-655 Newark NJ USA 07103
Citazione:
R. Labib et al., "Oral cocaine produces dose-related hepatotoxicity in male mice", TOX LETT, 125(1-3), 2001, pp. 29-37

Abstract

Cocaine remains a widely abused substance. While most addicts take cocaineintranasally, a considerable number abuse cocaine by mouth. It has been assumed that after oral exposure cocaine is hydrolyzed in the stomach rendering it ineffective. This study investigated the effect of orally administered cocaine on liver function and integrity as well as its effect on liver and blood antioxidative enzymes. Male CF-I mice were orally administered either 0, 5, 10 or 20 mg cocaine/kg body weight and sacrificed 24 h after the last treatment. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured as markers of liver injury. Blood and liver glutathione (GSH) levels were determined as well as the activities of glutathione peroxidase (GPx) and catalase (CAT). In addition, the activity of liverglutathione reductase (GRx) was also measured. The results demonstrated that oral cocaine caused hepatotoxicity in a dose dependent manner. Serum ALTand AST were elevated while blood GSH concentration decreased in all cocaine treated animals. In addition, there was a significant dose dependent decrease in the activities of GPx and CAT in blood and liver of cocaine treated animals. However, hepatic GSH content and GRx activity manifested a significant increase, particularly in the group, which received 20 mg/kg cocaine. This study is the first to demonstrate that cocaine-induced hepatotoxicity results following the oral route of administration. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 02/04/20 alle ore 12:37:45