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Titolo:
Postoperative patterns and kinetics of cTnI, cTnT CK-MB-activity and CK-activity after elective aortic valve replacement
Autore:
Opfermann, UT; Peivandi, AA; Dahm, M; Hilgenstock, H; Hafner, G; Loos, A; Oelert, H;
Indirizzi:
Univ Hosp Mainz, Dept Cardiothorac & Vasc Surg, D-55131 Mainz, Germany Univ Hosp Mainz Mainz Germany D-55131 Vasc Surg, D-55131 Mainz, Germany Univ Mainz, Inst Clin Chem, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 z, Inst Clin Chem, D-6500 Mainz, Germany Univ Mainz, Inst Med Stat & Documentat, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 Stat & Documentat, D-6500 Mainz, Germany
Titolo Testata:
SWISS MEDICAL WEEKLY
fascicolo: 37-38, volume: 131, anno: 2001,
pagine: 550 - 555
SICI:
1424-7860(20010922)131:37-38<550:PPAKOC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC TROPONIN-I; PERIOPERATIVE MYOCARDIAL-INFARCTION; HUMAN SKELETAL-MUSCLE; BIOCHEMICAL MARKERS; SURGERY; INJURY; DAMAGE;
Keywords:
aortic valve replacement; cardiac troponin I; cardiac troponin T;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Opfermann, UT Univ Hosp Mainz, Dept Cardiothorac & Vasc Surg, Langenbeckstr 1, D-55131 Mainz, Germany Univ Hosp Mainz Langenbeckstr 1 Mainz Germany D-55131 rmany
Citazione:
U.T. Opfermann et al., "Postoperative patterns and kinetics of cTnI, cTnT CK-MB-activity and CK-activity after elective aortic valve replacement", SWISS MED W, 131(37-38), 2001, pp. 550-555

Abstract

Objectives: The aim of this prospective study was to evaluate postoperative kinetics of four different biochemical ischaemic markers after elective aortic valve replacement (AVR). Additionally, pre-, peri- and postoperative data were analysed in order to identify factors with possible impact on thepostoperative release of the selected enzymes. Design: Forty patients (14 males, 26 females, aged 70 +/- 11 years; EF = 54 +/- 18% [mean +/- SD]) undergoing elective AVR were prospectively included in this study. For all patients, serum concentrations of cTnI, cTnT, and serum activities of CK-MB and CK were measured preoperatively as well as 0,6, 12, 24, 48 and 120 hours after reirioval of the aortic cross-clamp. Clinical data were assessed in all patients and correlated with postoperative enzyme patterns. Results: There were no major complications. Preoperatively, all patients showed enzyme values in the normal range whereas the four ischaemic markers reached higher values postoperatively. cTnI reached its maximum values 24 hours (X-Med = 2.35 mug/L, 95%-CI [2.0,3.3]) and cTnT 48 hours after the operation (X-Med = 0.239 mug/L, 95%-CI [0.174, 0.283]). Typical biphasic release kinetics could be demonstrated for cTnT. There was a high linear correlation between cTnI and cTnT at all sampling times. In contrast, a high linear correlation between cTnI, cTnT, and CK-MB-activity was only found 48 hours after aortic unclamping. cTnI nearly was in normal range 120 h postoperatively X-Med = 0.5 mu /L, 95%-CI [0.2, 0.6]), whereas cTnT still remained pathologically, elevated(X-Med = 0.223 mug/L, 95%-CI[0.137, 0.299]). No linear correlation was found between maximum values of the ischaemic markers postoperatively and age, gender, body surface area, ejection fraction, LV-hypertrophy, operating time, ECC time, time of cardiac arrest, lowest body, temperature, perfusion pressure, cardioplegia volume, reperfusion time, postoperative septiformic circulatory instability, or ventilation time. Conclusions: All four ischaemic markers showed individual peak characteristics and kinetics after uncomplicated AVR. In contrast to previous findings, aortic cross-clamping time had no detectable impact on postoperative peakpatterns of any ischaemic marker.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 07:06:27