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Titolo:
Ubiquitin proteasome pathway: implications and advances in cancer therapy
Autore:
Shah, SA; Potter, MW; Callery, MP;
Indirizzi:
Univ Massachusetts, Med Ctr, Dept Surg, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 t Surg, Worcester, MA 01655 USA
Titolo Testata:
SURGICAL ONCOLOGY-OXFORD
fascicolo: 1-2, volume: 10, anno: 2001,
pagine: 43 - 52
SICI:
0960-7404(200107/08)10:1-2<43:UPPIAA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; MULTICATALYTIC PROTEINASE COMPLEX; PROGRAMMED CELL-DEATH; KINASE INHIBITOR P27; CYCLIN DESTRUCTION; INDUCED APOPTOSIS; CARCINOMA-CELLS; MELANOMA-CELLS; SOLID TUMORS; U937 CELLS;
Keywords:
NF-kappa B; apoptosis; p53; p27; p21; chemoresistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Callery, MP Univ Massachusetts, Med Ctr, Dept Surg, 55 Lake Ave N, Worcester, MA 01655USA Univ Massachusetts 55 Lake Ave N Worcester MA USA 01655 655USA
Citazione:
S.A. Shah et al., "Ubiquitin proteasome pathway: implications and advances in cancer therapy", SURG ONCOL, 10(1-2), 2001, pp. 43-52

Abstract

The degradation of most eukaryotic cells is controlled by the ubiquitin proteasome pathway. This pathway is responsible not only for the degradation of short and long-lived proteins but also tumor suppressors, transcription factors arid cell cycle proteins. Altered degradation of these proteins is thought to promote cancer growth and spread. By contrast, inhibition of the,proteasome would lead to cell cycle arrest and ultimately programmed cell death, or apoptosis. A structured review of the published literature examining the role of ubiquitin proteasome inhibition in cancer growth and regulation is provided. Advances in the development of proteasome inhibitors haveallowed detailed investigation of this pathway in cancer growth. Relevant in vitro and in vivo studies of proteasome inhibition as pertains to cancertherapy are detailed. The ubiquitin proteasome pathway is critical in the degradation of proteins involved in cell cycle control and tumor growth. Proteasome inhibitors have been shown to arrest or retard cancer progression,by interfering with the ordered, temporal degradation of regulatory molecules. Clinical trials examining the agents have begun. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:25:39