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Titolo:
Caudoputamen is damaged by hypocapnia during mechanical ventilation in a rat model of chronic cerebral hypoperfusion
Autore:
Miyamoto, E; Tomimoto, H; Nakao, S; Wakita, H; Akiguchi, I; Miyamoto, K; Shingu, K;
Indirizzi:
Kyoto Univ, Fac Med, Dept Neurol, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 pt Neurol, Sakyo Ku, Kyoto 6068507, Japan Kansai Med Univ, Dept Anesthesiol, Osaka, Japan Kansai Med Univ Osaka Japan ai Med Univ, Dept Anesthesiol, Osaka, Japan
Titolo Testata:
STROKE
fascicolo: 12, volume: 32, anno: 2001,
pagine: 2920 - 2925
SICI:
0039-2499(200112)32:12<2920:CIDBHD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; HUMAN CAUDATE-NUCLEUS; WHITE-MATTER CHANGES; TRANSIENT FOREBRAIN ISCHEMIA; POSTOPERATIVE DELIRIUM; DISEASE PATIENTS; BASAL GANGLIA; WISTAR RATS; WATER MAZE; BLOOD-FLOW;
Keywords:
caudate nucleus; cerebral hypocapnia; delirium; hypocapnia; postoperative complications; putamen; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Tomimoto, H Kyoto Univ, Fac Med, Dept Neurol, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 akyo Ku, Kyoto 6068507, Japan
Citazione:
E. Miyamoto et al., "Caudoputamen is damaged by hypocapnia during mechanical ventilation in a rat model of chronic cerebral hypoperfusion", STROKE, 32(12), 2001, pp. 2920-2925

Abstract

Background and Purpose-Postoperative brain dysfunction, such as delirium, is a common complication of anesthesia and is sometimes prolonged, especially in patients with cerebrovascular disease. In the present study we investigated the effect of hypocapnia during anesthesia on neuronal damage using a rat model of chronic cerebral hypoperfusion. Methods-Chronic cerebral hypoperfusion was induced by clipping the bilateral common carotid arteries in male Wistar rats. Fourteen days after the operation. these animals were mechanically ventilated For 2 hours and then kept in suitable conditions for an additional 14 days. Twenty-four rats were assigned to 4 groups: those with chronic cerebral hypoperfusion with either hypocapnia or normocapnia during anesthesia, and those given sham operationwith either hypocapnia or normocapnia. White matter lesions in the brain sections were evaluated with Kluver-Barrera staining. Proliferation of glialcells was estimated with the use of immunohistochemistry of glial fibrillary acidic protein, a marker for astroglia. and CD11b, a marker for microglia. Computer-assisted morphometry was applied to the immunohisto- chemical results of microtubule-associated protein 2 to evaluate the loss of neurons. Results-The histological damage was localized almost exclusively in the white matter in the rats subjected to chronic cerebral hypoperfusion but without hypocapnia. Neuronal damage and astroglial proliferation occurred with aggravated white matter lesions in the caudoputamen in the rats with chronic cerebral hypoperfusion and hypocapnia. No lesions were observed in sham-operated rats with either hypocapnia or normocapnia. Conclusions-These results indicate that hypocapnia during anesthesia causes tissue damage in the caudoputamen, which may be responsible for long-lasting postoperative delirium in patients with stroke and/or dementia.

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Documento generato il 18/01/20 alle ore 07:38:58