Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pravastatin improves cerebral vasomotor reactivity in patients with subcortical small-vessel disease
Autore:
Sterzer, P; Meintzschel, F; Rosler, A; Lanfermann, H; Steinmetz, H; Sitzer, M;
Indirizzi:
Univ Frankfurt, Dept Neurol, D-60528 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60528 rol, D-60528 Frankfurt, Germany Univ Frankfurt, Dept Neuroradiol, Frankfurt, Germany Univ Frankfurt Frankfurt Germany , Dept Neuroradiol, Frankfurt, Germany
Titolo Testata:
STROKE
fascicolo: 12, volume: 32, anno: 2001,
pagine: 2817 - 2820
SICI:
0039-2499(200112)32:12<2817:PICVRI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; TRANSCRANIAL DOPPLER SONOGRAPHY; DEPENDENT CORONARY VASOMOTION; CHOLESTEROL-LOWERING THERAPY; HYPERCHOLESTEROLEMIC PATIENTS; CARBON-DIOXIDE; BLOOD-FLOW; ACETAZOLAMIDE; ENDOTHELIUM; STROKE;
Keywords:
endothelium; HMG-CoA reductase inhibitors; small-vessel disease; ultrasonography; vasomotor reactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sterzer, P Univ Frankfurt, Dept Neurol, Schleusenweg 2-16, D-60528 Frankfurt, Germany Univ Frankfurt Schleusenweg 2-16 Frankfurt Germany D-60528 any
Citazione:
P. Sterzer et al., "Pravastatin improves cerebral vasomotor reactivity in patients with subcortical small-vessel disease", STROKE, 32(12), 2001, pp. 2817-2820

Abstract

Background and Purpose-Recent investigations have suggested an important role of statins in the prevention of stroke CIP and dementia independent of their lipid-lowering, properties. Using transcranial Doppler sonography (TCD), we examined acetazolamide reactivity as a marker of cerebral vasoreactivity in patients with subcortical small-vessel disease before and after pravastatin treatment. Methods-In 16 patients (mean age 68 +/- 10 years) with subcortical small-vessel disease, cerebral vasomotor reactivity was tested using TCD insonating the middle cerebral artery. Cerebral blood flow velocity (CBFV) increase after bolus injection of 1 g acetazolamide was determined before and after 2-month treatment with pravastatin sodium 20 mg daily. Results-Relative CBFV increase was significantly greater after pravastatintreatment (41.9 +/- 23.7% versus 55.7 +/- 8.3%, P = 0.004). Comparison of CBFV at rest before and after treatment with pravastatin did not show significant differences, There was a strong negative correlation between the pravastatin-induced enhancement of vasomotor reactivity and the pretreatment CBFV increase (beta = -0.64, P = 0.019). No associations were found between the effect of pravastatin on vasomotor reactivity and pretreatment levels or changes of LDL cholesterol. Conclusions-This pilot study provides the first evidence for a significantimprovement of cerebral vasomotor reactivity by statin therapy in patientswith cerebral small-vessel disease. The results may help to elucidate the preventive effect of statins and provide insights into the pathophysiology of cerebral small-vessel disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:31:45