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Titolo:
Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke
Autore:
Montaner, J; Alvarez-Sabin, J; Molina, CA; Angles, A; Abilleira, S; Arenillas, J; Monasterio, J;
Indirizzi:
Hosp Vall dHebron, Gen Hosp, Neurol Serv, Cerebrovasc Unit, Barcelona 08035, Spain Hosp Vall dHebron Barcelona Spain 08035 asc Unit, Barcelona 08035, Spain Vall dHebron Hosp, Hemostasia Res Unit, Barcelona, Spain Vall dHebron Hosp Barcelona Spain Hemostasia Res Unit, Barcelona, Spain
Titolo Testata:
STROKE
fascicolo: 12, volume: 32, anno: 2001,
pagine: 2762 - 2767
SICI:
0039-2499(200112)32:12<2762:MMEIRT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC STROKE; REPERFUSION; COLLAGENASE; INHIBITION; INFARCT; BRAIN; RATS;
Keywords:
cerebral ischemia; embolism, cerebral; hematoma, parenchymal; hemorrhagic stroke; matrix metalloproteinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Montaner, J Hosp Vall dHebron, Gen Hosp, Neurol Serv, Cerebrovasc Unit, 6 Planta,Pg Vall dHebron 119-129, Barcelona 08035, Spain Hosp Vall dHebron 6 Planta,Pg Vall dHebron 119-129 Barcelona Spain 08035
Citazione:
J. Montaner et al., "Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke", STROKE, 32(12), 2001, pp. 2762-2767

Abstract

Background and Purpose-In animal models of cerebral ischemia, matrix metalloproteinase (MMP) expression was significantly increased and related to blood-brain barrier disruption, edema formation, and hemorrhagic transformation HT). MMP inhibitors reduce HT after embolic ischemia in tissue-type plasminogen activator-treated animals. We aimed to determine the relationship between MMPs and HT after human ischemic stroke. Methods-Serial MMP-2 and MMP-9 determinations were performed by means of ELISA in 39 cardioembolic strokes in the middle cerebral artery territory. Hemorrhagic events were classified according to clinical and CT criteria (hemorrhagic infarction [HI] and parenchymal hematoma [PH]). HT was evaluated on CT at 48 hours (early HT) and again between day 5 and 7 (late HT). Results-HT was present in 41%, of the patients (43.75% early HI, 25%( early PH and 31.25% late HI). MMP-2 values were within normal range and were unrelated to HT. Increased expression of MMP-9 (normal range < 97 ng/mL) was found among patients with and without HT (159.3 +/- 82 versus 143.9 +/- 112.6 ng/mL P = 0.64). According to HT subtypes, the highest baseline MMP-9 levels corresponded to patients with late HI (240.4 +/- 111.2 versus 102.5 +/- 76.7 ng/mL for all other patients, P = 0.002). Baseline MMP-9 was the only variable associated with late HI in the multiple logistic regression model (OR 9; CI 1.46. 55.24; P = 0.010). Peak of MMP-9 at the 24-hour time point (250.6 ng/mL) was found before appearance of PH. Conclusions-MMPs are involved in some subtypes of HT after human cardioembolic stroke. Baseline MMP-9 level predicts late HI and a 24-hour peak precedes early PH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:54:17