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Titolo:
Efficacy, safety and predictive factors of therapeutic success with sildenafil for erectile dysfunction in patients with different spinal cord injuries
Autore:
Ramos, AS; Vidal, J; Jauregui, ML; Barrera, M; Recio, C; Giner, M; Toribio, L; Salvador, S; Sanmartin, A; de la Fuente, M; Santos, JF; de Juan, FJ; Moraleda, S; Mendez, JL; Ramirez, L; Casado, RM;
Indirizzi:
Hosp Nacl Paraplejicos, Dept Sexual & Reprod, Toledo, Spain Hosp Nacl Paraplejicos Toledo Spain Dept Sexual & Reprod, Toledo, Spain Inst Guttman, Barcelona, Spain Inst Guttman Barcelona SpainInst Guttman, Barcelona, Spain Hosp Cruces, Bilbao, Spain Hosp Cruces Bilbao SpainHosp Cruces, Bilbao, Spain Hosp Virgen Rocio, Seville, Spain Hosp Virgen Rocio Seville SpainHosp Virgen Rocio, Seville, Spain Hosp Puerta Mar, Cadiz, Spain Hosp Puerta Mar Cadiz SpainHosp Puerta Mar, Cadiz, Spain Hosp La Fe, E-46009 Valencia, Spain Hosp La Fe Valencia Spain E-46009Hosp La Fe, E-46009 Valencia, Spain Hosp Miguel Servet, Zaragoza, Spain Hosp Miguel Servet Zaragoza SpainHosp Miguel Servet, Zaragoza, Spain Hosp Juan Canalejo, La Coruna, Spain Hosp Juan Canalejo La Coruna SpainHosp Juan Canalejo, La Coruna, Spain Hosp Gen Asturias, E-33006 Oviedo, Spain Hosp Gen Asturias Oviedo Spain E-33006 n Asturias, E-33006 Oviedo, Spain Hosp Virgen Nieves, Granada, Spain Hosp Virgen Nieves Granada SpainHosp Virgen Nieves, Granada, Spain Hosp Juan XXIII, Tarragona, Spain Hosp Juan XXIII Tarragona SpainHosp Juan XXIII, Tarragona, Spain Clin Povisa, Vigo, Spain Clin Povisa Vigo SpainClin Povisa, Vigo, Spain Hosp La Paz, Madrid, Spain Hosp La Paz Madrid SpainHosp La Paz, Madrid, Spain Hosp Insular, Las Palmas de Gran Canaria, Spain Hosp Insular Las Palmas de Gran Canaria Spain as de Gran Canaria, Spain Hosp Valle De Hebron, Barcelona, Spain Hosp Valle De Hebron Barcelona Spain Valle De Hebron, Barcelona, Spain Fdn Rehabil Lesionado Medular, Madrid, Spain Fdn Rehabil Lesionado Medular Madrid Spain onado Medular, Madrid, Spain
Titolo Testata:
SPINAL CORD
fascicolo: 12, volume: 39, anno: 2001,
pagine: 637 - 643
SICI:
1362-4393(200112)39:12<637:ESAPFO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEN; PHYSIOLOGY;
Keywords:
erectile dysfunction; spinal cord injury; sildenafil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Ramos, AS Hosp Nacl Paraplejicos, Dept Sexual & Reprod, Finca Peraleda S-N, Toledo, Spain Hosp Nacl Paraplejicos Finca Peraleda S-N Toledo Spain , Spain
Citazione:
A.S. Ramos et al., "Efficacy, safety and predictive factors of therapeutic success with sildenafil for erectile dysfunction in patients with different spinal cord injuries", SPINAL CORD, 39(12), 2001, pp. 637-643

Abstract

Study design: Multicenter, open, prospective, before-after study. Objective: To assess the efficacy and safety of sildenafil therapy for erectile dysfunction in patients with spinal cord injury, and the association between the response to sildenafil and factors such as causes and levels ofspinal cord injury, grade of ASIA deficit, time since injury, orgasmic perception, and degree of baseline erection. Setting: Homes of outpatients of 16 spinal cord injury units in Spain. Method: One hundred and seventy patients with erectile dysfunction secondary to spinal cord injury, from whom baseline data were collected on their sexual function, and who started treatment with sildenafil 50 mg. An efficacy assessment was made by the patient and his partner, and the score of the International Index of Erectile Function (IIEF) was recorded. Results: It was reported by 88.2% of the patients and 85.3% of their partners that treatment with sildenafil had improved their erections, regardlessof the baseline characteristics of the spinal cord injury and erectile function. In responders, this improvement was confirmed by an increase from 12.5 to 24.8 points (P < 0.001) of the Erectile Function Domain of IIEF. A significant improvement was also seen in patients' satisfaction with sexual activity and general satisfaction derived from sexual life. Preservation of orgasmic perception and a baseline degree of erection of 3 or 4 (P = 0.006)were predictors of therapeutic success. No serious adverse events occurred. Conclusion: Sildenafil is an effective, well-tolerated treatment for erectile dysfunction caused by spinal cord injury, regardless of the cause, neurological level, ASIA grade, and time since injury. Sponsorship: Spanish Society of Paraplegia.

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Documento generato il 05/04/20 alle ore 08:36:50