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Titolo:
Discrepant outcome between myocardial energy-related metabolites and infarct size limitation during retroperfusion of the coronary sinus
Autore:
Zemgulis, V; Wikstrom, G; Bjerner, T; Henze, A; Lahtinen, M; Waldenstrom, A; Thelin, S; Ronquist, G;
Indirizzi:
Univ Uppsala Hosp, Dept Thorac & Cardiovasc Surg, SE-75185 Uppsala, SwedenUniv Uppsala Hosp Uppsala Sweden SE-75185 Surg, SE-75185 Uppsala, Sweden Univ Uppsala Hosp, Dept Cardiol, SE-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden SE-75185 diol, SE-75185 Uppsala, Sweden Univ Uppsala Hosp, Dept Diagnost Radiol, SE-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden SE-75185 diol, SE-75185 Uppsala, Sweden Univ Uppsala Hosp, Dept Clin Chem, SE-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden SE-75185 Chem, SE-75185 Uppsala, Sweden Umea Univ Hosp, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden Umea Univ Hosp Umea Sweden S-90185 Hlth & Clin Med, S-90185 Umea, Sweden
Titolo Testata:
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
fascicolo: 8, volume: 61, anno: 2001,
pagine: 651 - 662
SICI:
0036-5513(2001)61:8<651:DOBMEM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIASTOLIC SYNCHRONIZED RETROPERFUSION; ISCHEMIC MYOCARDIUM; VENOUS RETROPERFUSION; ARTERY OCCLUSION; BLOOD-FLOW; PRELIMINARY EXPERIENCE; PERFUSION; SUPPORT; VEINS; PRESERVATION;
Keywords:
energy metabolism; ischemia; microdialysis; pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Zemgulis, V Univ Uppsala Hosp, Dept Thorac & Cardiovasc Surg, SE-75185 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden SE-75185 85 Uppsala, Sweden
Citazione:
V. Zemgulis et al., "Discrepant outcome between myocardial energy-related metabolites and infarct size limitation during retroperfusion of the coronary sinus", SC J CL INV, 61(8), 2001, pp. 651-662

Abstract

The basic idea of retroperfusion of the coronary sinus (RCS) is to ameliorate detrimental consequences of myocardial ischaemia. Several experimental models of RCS have been introduced. most with an emphasis on functional myocardial status. Since only few studies have been devoted to energy metabolic considerations and none to continuous monitoring of energy-related metabolites of myocardium during RCS. we here present such a study using microdialysis. This study comprised the following components: Coronary occlusion and drainage on the beating heart with RCS-assist (60 min), hypothermic (30 degreesC) extracorporeal circulation (ECC) and cardioplegia (45 min), reperfusion and rewarming to 38 degreesC on ECC (30 min). The microdialysis analytical outcome mainly reflected anaerobic energy metabolism in potentially ischaemic myocardium. Additionally, a pronounced increase of microdialysate content of lactate, pyruvate and guanosine was observed in non-ischaemic myocardium especially during the reperfusion phase. The planimetric calculation revealed an infarct size reduction from 69% to 19% and was not correlated to clear-cut improvements of potentially ischaemic myocardial energy metabolism. We conclude that prolonged (60 min) anaerobic energy metabolism does not pose an immediate threat to cell viability but could even sustain myocyte survival.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:59:05