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Titolo:
Solid-phase analysis method for (S)-[F-18]fluorocarazolol and its metabolites
Autore:
Muzic, RF; Landmeier, B; Zhang, Z; Zheng, L; Berridge, MS;
Indirizzi:
Case Western Reserve Univ, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 2, volume: 759, anno: 2001,
pagine: 355 - 359
SICI:
1387-2273(20010815)759:2<355:SAMF
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENOCEPTORS; QUANTIFICATION; PULMONARY; PET;
Keywords:
fluorocarazolol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Muzic, RF Univ Hosp Cleveland, 11100 Euclid Ave, Cleveland, OH 44106 USA Univ Hosp Cleveland 11100 Euclid Ave Cleveland OH USA 44106 USA
Citazione:
R.F. Muzic et al., "Solid-phase analysis method for (S)-[F-18]fluorocarazolol and its metabolites", J CHROMAT B, 759(2), 2001, pp. 355-359

Abstract

(S)-[F-18]Fluorocarazolol is a radiopharmaceutical developed to quantitatively assess P-adrenergic receptors in vivo via positron emission tomographyimaging. Since radioactive metabolites of (S)-[F-18]fluorocarazolol rapidly appear in the plasma, methods for conveniently and reliably evaluating plasma for (S)-[F-18]fluorocarazolol content are required. Here we present methods and validation of an approach using commercial extraction cartridges that is faster and more convenient than an approach using internal-surface reverse-phase chromatography but yields comparable results. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 14:35:26