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Titolo:
Capillary electrophoretic separation of protease inhibitors used in human immunodeficiency virus therapy
Autore:
Gutleben, W; Tuan, ND; Stoiber, H; Dierich, MP; Sarcletti, M; Zemann, A;
Indirizzi:
Innsbruck Univ, Inst Analyt Chem & Radiochem, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 ochem, A-6020 Innsbruck, Austria Innsbruck Univ, Inst Hyg & Social Med, A-6020 Innsbruck, Austria InnsbruckUniv Innsbruck Austria A-6020 l Med, A-6020 Innsbruck, Austria Innsbruck Univ, L Boltzmann Inst AIDS Res, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 S Res, A-6020 Innsbruck, Austria Innsbruck Univ, Dept Dermatol & Venerol, A-6020 Innsbruck, Austria Innsbruck Univ Innsbruck Austria A-6020 nerol, A-6020 Innsbruck, Austria Univ Med & Pharm Ho Chi Minh Cit, Fac Pharm, Ho Chi Minh City, Vietnam Univ Med & Pharm Ho Chi Minh Cit Ho Chi Minh City Vietnam City, Vietnam
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY A
fascicolo: 1-2, volume: 922, anno: 2001,
pagine: 313 - 320
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; HUMAN PLASMA; CEREBROSPINAL-FLUID; ULTRAVIOLET DETECTION; RITONAVIR; INDINAVIR; SAQUINAVIR; AMPRENAVIR; NELFINAVIR;
Keywords:
human immunodeficiency virus; pharmaceutical analysis; protease inhibitors; enzyme inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Zemann, A Innsbruck Univ, Inst Analyt Chem & Radiochem, Innrain 52A, A-6020 Innsbruck, Austria Innsbruck Univ Innrain 52A Innsbruck Austria A-6020 ck, Austria
Citazione:
W. Gutleben et al., "Capillary electrophoretic separation of protease inhibitors used in human immunodeficiency virus therapy", J CHROMAT A, 922(1-2), 2001, pp. 313-320

Abstract

The scope of this work was to investigate the migration behavior of the currently used protease inhibitors for antiretroviral therapy of people infected with the human immunodeficiency virus and to develop a method for theircapillary electrophoretic separation and determination. All of the protease inhibitors (indinavir, saquinavir, nelfinavir, amprenavir, and ritonavir)contain at least one basic amino functional group. As a consequence, they can be separated by capillary zone electrophoresis using acidic buffer electrolytes. A fast electroosmotic flow is established in order to increase separation speed, by adding a cationic electroosmotic flow modifier to the electrolyte. After using conventional serum pretreatment procedures it is possible to separate all five protease inhibitors within less than 5 min. In addition, a non-aqueous CE method is also presented which enables the separation of three protease inhibitor compounds within less than 3 min. (C) 2001Elsevier Science B.V. All rights reserved.

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Documento generato il 18/01/20 alle ore 07:33:19