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Titolo:
Amyloid beta peptide levels and its effects on hippocampal acetylcholine release in aged, cognitively-impaired and -unimpaired rats
Autore:
Vaucher, E; Aumont, N; Pearson, D; Rowe, W; Poirier, J; Kar, S;
Indirizzi:
McGill Univ, Douglas Hosp, Res Ctr, Dept Psychiat, Montreal, PQ H4H 1R3, Canada McGill Univ Montreal PQ Canada H4H 1R3 hiat, Montreal, PQ H4H 1R3, Canada
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 4, volume: 21, anno: 2001,
pagine: 323 - 329
SICI:
0891-0618(200106)21:4<323:ABPLAI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRECURSOR PROTEIN; ALZHEIMERS-DISEASE; CHOLINERGIC MARKERS; MEMORY DEFICITS; BASAL FOREBRAIN; CEREBRAL-CORTEX; IN-VIVO; NEURONS; DYSFUNCTION; METABOLISM;
Keywords:
aging; Alzheimer's disease; amyloid precursor protein; cognition; neuromodulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kar, S McGill Univ, Douglas Hosp, Res Ctr, Dept Psychiat, Montreal, PQ H4H1R3, Canada McGill Univ Montreal PQ Canada H4H 1R3 ontreal, PQ H4H 1R3, Canada
Citazione:
E. Vaucher et al., "Amyloid beta peptide levels and its effects on hippocampal acetylcholine release in aged, cognitively-impaired and -unimpaired rats", J CHEM NEUR, 21(4), 2001, pp. 323-329

Abstract

Excessive extracellular deposition of amyloid beta (A beta) peptide in neuritic plaques and degeneration of forebrain cholinergic neurones, which innervate the hippocampus and the neocortex. are the invariant characteristic features of Alzheimer's disease (AD). Studies of the pathological changes that characterize AD, together with several other lines of evidence, indicate that A beta accumulation in vivo may initiate and!or contribute to the process of neurodegeneration observed in the AD brain. However, the underlying mechanisms by which A beta peptide influences/causes degeneration of the basal forebrain cholinergic neurones in AD brains remain obscure. We reported earlier that nM concentrations of A beta -related peptides. under acute conditions, can potently inhibit K+-evoked endogenous acetylcholine (ACh) release from the hippocampus and the cortex but not from striatum in young adult rats (J. Neurosci. 16 (1996) 1034). In the present study, to determinewhether the effects of A beta peptides alter with normal aging and/or cognitive state, we have measured A beta (1-40) levels and the effects of exogenous A beta (1-40) on hippocampal ACh release in young adult as well as aged cognitively-unimpaired (AU) and -impaired (AI) rats. Endogenous levels ofA beta (1-40) in the hippocampus are significantly increased in aged rats. Additionally, 10 nM A beta (1-40) potently inhibited endogenous ACh release from the hippocampus of the three groups of rats, but the time-course of the effects clearly indicate that the cholinergic neurones of AI rats are more sensitive to A beta peptides than either AU or young adult rats. These results, together with earlier reports, suggest that the processing of the precursor protein of A beta peptide alters with normal aging and the response of the cholinergic neurones to the peptide possibly varies with the cognitive status of the animals. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:29:00