Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions
Autore:
Xu, X; Li, WEI; Huang, GY; Meyer, R; Chen, T; Luo, Y; Thomas, MP; Radice, GL; Lo, CW;
Indirizzi:
Univ Penn, Goddard Lab, Dept Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dept Biol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Ctr Res Reprod & Womens Hlth, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 mens Hlth, Philadelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF CELL BIOLOGY
fascicolo: 1, volume: 154, anno: 2001,
pagine: 217 - 229
SICI:
0021-9525(20010709)154:1<217:MOMNCC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIO-FACIAL SYNDROME; XENOPUS EMBRYOS; P120 CATENIN; PROTEIN CONNEXIN-43; CYTOPLASMIC DOMAIN; ADHESION MOLECULES; ADHERENS JUNCTION; EXPRESSION; COMMUNICATION; GENE;
Keywords:
cadherin; connexin; wnt; neural crest; catenin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Lo, CW Univ Penn, Goddard Lab, Dept Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 ol, Philadelphia, PA 19104 USA
Citazione:
X. Xu et al., "Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions", J CELL BIOL, 154(1), 2001, pp. 217-229

Abstract

Connexin 43 (Cx43 alpha1) gap junction has been shown to have an essentialrole in mediating functional coupling of neural crest cells and in modulating neural crest cell migration. Here, we showed that N-cadherin and wnt1 are required for efficient dye coupling but not for the expression of Cx43 alpha1 gap junctions in neural crest cells. Cell motility was found to be altered in the N-cadherin-deficient neural crest cells, but the alterations were different from that elicited by Cx43 alpha1 deficiency. In contrast, wnt1-deficient neural crest cells showed no discernible change in cell motility. These observations suggest that dye coupling may not be a good measure of gap junction communication relevant to motility. Alternatively, Cx43 alpha1 may serve a novel function in motility. We observed that p120 catenin (p120ctn), an Armadillo protein known to modulate cell motility, is colocalized not only with N-cadherin but also with Cx43 alpha1. Moreover, the subcellular distribution of p120ctn was altered with N-cadherin or Cx43 alpha1 deficiency. Based on these findings, we propose a model in which Cx43 alpha1and N-cadherin may modulate neural crest cell motility by engaging in a dynamic cross-talk with the cell's locomotory apparatus through p120ctn signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:37:34