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Titolo:
Dopamine acutely stimulates Na+/H+ exchanger (NHE3) endocytosis via clathrin-coated vesicles - Dependence on protein kinase A-mediated NHE3 phosphorylation
Autore:
Hu, MC; Fan, LZ; Crowder, LA; Karim-Jimenez, Z; Murer, H; Moe, OW;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 r, Dept Internal Med, Dallas, TX 75390 USA Dept Vet Affairs Med Ctr, Med Serv, Dallas, TX 75216 USA Dept Vet Affairs Med Ctr Dallas TX USA 75216 d Serv, Dallas, TX 75216 USA Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 siol, CH-8057 Zurich, Switzerland
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 29, volume: 276, anno: 2001,
pagine: 26906 - 26915
SICI:
0021-9258(20010720)276:29<26906:DASNE(>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL BRUSH-BORDER; PROXIMAL CONVOLUTED TUBULE; K+-ATPASE ACTIVITY; SPONTANEOUSLY HYPERTENSIVE RATS; SODIUM-EXCRETION; NA+,K+-ATPASE ACTIVITY; PARATHYROID-HORMONE; VOLUME EXPANSION; PHOSPHATIDYLINOSITOL 3-KINASE; TRANSPORT VESICLES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
114
Recensione:
Indirizzi per estratti:
Indirizzo: Moe, OW Univ Texas, SW Med Ctr, Dept Internal Med, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 TX 75390 USA
Citazione:
M.C. Hu et al., "Dopamine acutely stimulates Na+/H+ exchanger (NHE3) endocytosis via clathrin-coated vesicles - Dependence on protein kinase A-mediated NHE3 phosphorylation", J BIOL CHEM, 276(29), 2001, pp. 26906-26915

Abstract

Dopamine (DA) is a key hormone in mammalian sodium homeostasis. DA inducesnatriuresis via acute inhibition of the renal proximal tubule apical membrane Na+/H+ exchanger NHE3. We examined the mechanism by which DA inhibits MHE3 in a renal cell line. DA acutely decreases surface NHE3 antigen in dose- and time-dependent fashion without altering total cellular NHE3. AlthoughDA, receptor agonist alone decreases surface NHE3, simultaneous DA, agonist synergistically enhances the effect of DA,, Decreased surface NHE3 antigen, caused by stimulation of NHE3 endocytosis, is dependent on intact functioning of the GTPase dynamin and involves increased binding of NHE3 to the adaptor protein AP2, DA-stimulated NHE3 endocytosis can be blocked by pharmacologic or genetic protein kinase A inhibition or by mutation of two protein kinase A target serines (Ser-560 and Ser-613) on NRE3, We conclude that one mechanism by which DA induces natriuresis is via protein kinase A-mediated phosphorylation of proximal tubule NHE3 leading to endocytosis of NHE3 via clathrin-coated vesicles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:40:43