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Titolo:
Signal transduction in smooth muscle - Invited review: Arteriolar smooth muscle mechanotransduction: Ca2+ signaling pathways underlying myogenic reactivity
Autore:
Hill, MA; Zou, H; Potocnik, SJ; Meininger, GA; Davis, MJ;
Indirizzi:
RMIT Univ, Sch Med Sci, Microvasc Biol Grp, Bundoora, Vic 3083, Australia RMIT Univ Bundoora Vic Australia 3083 Grp, Bundoora, Vic 3083, Australia Univ Massachusetts, Sch Med, Dept Physiol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 hysiol, Worcester, MA 01655 USA Texas A&M Univ, Coll Med, Dept Med Physiol, Cardiovasc Res Inst, College Stn, TX 77843 USA Texas A&M Univ College Stn TX USA 77843 s Inst, College Stn, TX 77843 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 973 - 983
SICI:
8750-7587(200108)91:2<973:STISM->2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CEREBRAL-ARTERIES; WHOLE-CELL CURRENTS; INCREASES INOSITOL TRISPHOSPHATE; REGULATED CHLORIDE CHANNELS; TRANSIENT OUTWARD CURRENTS; MESENTERIC SMALL ARTERIES; CALCIUM INFLUX FACTOR; FLUID SHEAR-STRESS; SARCOPLASMIC-RETICULUM; GUINEA-PIG;
Keywords:
arterioles; myogenic response; calcium entry; calcium signaling;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
125
Recensione:
Indirizzi per estratti:
Indirizzo: Hill, MA RMIT Univ, Sch Med Sci, Microvasc Biol Grp, Plenty Rd, Bundoora, Vic 3083,Australia RMIT Univ Plenty Rd Bundoora Vic Australia 3083 ic 3083,Australia
Citazione:
M.A. Hill et al., "Signal transduction in smooth muscle - Invited review: Arteriolar smooth muscle mechanotransduction: Ca2+ signaling pathways underlying myogenic reactivity", J APP PHYSL, 91(2), 2001, pp. 973-983

Abstract

The smooth muscle of arterioles responds to an increase in intraluminal pressure with vasoconstriction and with vasodilation when pressure is decreased. Such myogenic vasoconstriction provides a level of basal tone that enables arterioles to appropriately adjust diameter in response to neurohumoralstimuli. Key in this process of mechanotransduction is the role of changesin intracellular Ca2+. However, it is becoming clear that considerable complexity exists in the spatiotemporal characteristics of the Ca2+ signal andthat changes in intracellular Ca2+ may play roles other than direct effects on the contractile process via activation of myosin light-chain phosphorylation. The involvement of Ca2+ may extend to modulation of ion channels and release of Ca2+ from the sarcoplasmic reticulum, alterations in Ca2+ sensitivity, and coupling between cells within the vessel wall. The purpose of this brief review is to summarize the current literature relating to Ca2+ and the arteriolar myogenic response. Consideration is given to coupling of Ca2+ changes to the mechanical stimuli, sources of Ca2+, involvement of ionchannels, and spatiotemporal aspects of intracellular Ca2+ signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:49:05