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Titolo:
Signal transduction in smooth muscle - Invited review: Cross-bridge regulation by thin filament-associated proteins
Autore:
Morgan, KG; Gangopadhyay, SS;
Indirizzi:
Boston Biomed Res Inst, Signal Transduct Grp, Watertown, MA 02472 USA Boston Biomed Res Inst Watertown MA USA 02472 rp, Watertown, MA 02472 USA Beth Israel Deaconess Med Ctr, Div Cardiovasc, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 c, Boston, MA 02215 USA Harvard Univ, Sch Med, Boston, MA 02215 USA Harvard Univ Boston MA USA 02215 vard Univ, Sch Med, Boston, MA 02215 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 953 - 962
SICI:
8750-7587(200108)91:2<953:STISM->2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGHT-CHAIN PHOSPHORYLATION; ACTIN-BINDING SITES; ERK MAP KINASES; MYOSIN SUBFRAGMENT-1; CA2+ SENSITIVITY; BOVINE AORTA; F-ACTIN; CALDESMON PHOSPHORYLATION; H-CALDESMON; HUMAN SM22;
Keywords:
caldesmon; calponin; tropomyosin; SM22; preterm labor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Morgan, KG Boston Biomed Res Inst, Signal Transduct Grp, 64 Grove St, Watertown, MA 02472 USA Boston Biomed Res Inst 64 Grove St Watertown MA USA 02472 2 USA
Citazione:
K.G. Morgan e S.S. Gangopadhyay, "Signal transduction in smooth muscle - Invited review: Cross-bridge regulation by thin filament-associated proteins", J APP PHYSL, 91(2), 2001, pp. 953-962

Abstract

This minireview will cover current concepts on the identity and mechanistic function of smooth muscle actin binding proteins that may regulate actin-myosin interactions. The potential roles of tropomyosin, caldesmon, calponin, and SM22 will be discussed. The review, for purposes of brevity, will benonexhaustive but will give an overview of available information on the invitro biochemistry and potential in vivo function of these proteins. Preterm labor is discussed as a possible example of where thin filament regulation may be relevant. Considerable controversy surrounds the putative physiological significance of these proteins, and emphasis will be placed on the need for more experimental work to determine the degree to which tissue- andspecies-specific effects have clouded the interpretation of functional data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:29:12