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Titolo:
Signal transduction in smooth muscle - Historical perspective on airway smooth muscle: the saga of a frustrated cell
Autore:
Seow, CY; Fredberg, JJ;
Indirizzi:
Harvard Univ, Sch Publ Hlth, Physiol Program, Dept Environm Hlth, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Dept Environm Hlth, Boston, MA 02115 USA Univ British Columbia, St Pauls Hosp, Dept Pathol & Lab Med, Vancouver, BCV5Z 1M9, Canada Univ British Columbia Vancouver BC Canada V5Z 1M9 uver, BCV5Z 1M9, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 938 - 952
SICI:
8750-7587(200108)91:2<938:STISM->2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; LIGHT-CHAIN PHOSPHORYLATION; CHICKEN GIZZARD MUSCLE; DEEP INSPIRATION; LUNG-INFLATION; BRONCHIAL HYPERRESPONSIVENESS; SHORTENING VELOCITY; MYOSIN-FILAMENTS; COLLATERAL RESISTANCE; INDIVIDUAL AIRWAYS;
Keywords:
asthma; bronchospasm; obstruction; hyperresponsiveness; myosin; plasticity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
169
Recensione:
Indirizzi per estratti:
Indirizzo: Fredberg, JJ Harvard Univ, Sch Publ Hlth, Physiol Program, Dept Environm Hlth, 665 Huntington Ave, Boston, MA 02115 USA Harvard Univ 665 Huntington Ave Boston MA USA 02115 02115 USA
Citazione:
C.Y. Seow e J.J. Fredberg, "Signal transduction in smooth muscle - Historical perspective on airway smooth muscle: the saga of a frustrated cell", J APP PHYSL, 91(2), 2001, pp. 938-952

Abstract

Despite the lack of a clearly defined physiological function, airway smooth muscle receives substantial attention because of its involvement in the pathogenesis of asthma. Recent investigations have turned to the ways in which the muscle is influenced by its dynamic microenvironment. Ordinarily, airway smooth muscle presents little problem, even when maximally activated, because unending mechanical perturbations provided by spontaneous tidal breathing put airway smooth muscle in a perpetual state of "limbo," keeping its contractile machinery off balance and unable to achieve its force-generating potential. The dynamic microenvironment affects airway smooth muscle inat least two ways: by acute changes associated with disruption of myosin binding and by chronic changes associated with plastic restructuring of contractile and cytoskeletal filament organization. Plastic restructuring can occur when dynamic length changes occur between sequential contractile events or within a single contractile event. Impairment of these normal responses of airway smooth muscle to its dynamic environment may be implicated in airway hyperresponsiveness in asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:12:28