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Titolo:
Improved analysis of brachial artery ultrasound using a novel edge-detection software system
Autore:
Woodman, RJ; Playford, DA; Watts, GF; Cheetham, C; Reed, C; Taylor, RR; Puddey, IB; Beilin, LJ; Burke, V; Mori, TA; Green, D;
Indirizzi:
Univ Western Australia, Dept Med, Perth, WA 6001, Australia Univ Western Australia Perth WA Australia 6001 Perth, WA 6001, Australia Univ Western Australia, Dept Human Movement & Exercise Sci, Perth, WA 6001, Australia Univ Western Australia Perth WA Australia 6001 Perth, WA 6001, Australia Royal Perth Hosp, W Australian Heart Res Inst, Dept Cardiol, Perth, WA 6000, Australia Royal Perth Hosp Perth WA Australia 6000 rdiol, Perth, WA 6000, Australia Royal Perth Hosp, W Australian Heart Res Inst, Dept Med Phys, Perth, WA 6000, Australia Royal Perth Hosp Perth WA Australia 6000 Phys, Perth, WA 6000, Australia
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 929 - 937
SICI:
8750-7587(200108)91:2<929:IAOBAU>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; COMPUTERIZED ANALYZING SYSTEM; CONVERTING ENZYME-INHIBITION; CONGESTIVE-HEART-FAILURE; INTIMA-MEDIA THICKNESS; ENDOTHELIAL FUNCTION; NONINVASIVE MEASUREMENT; CAROTID-ARTERY; RISK-FACTORS; SAMPLE-SIZE;
Keywords:
flow-mediated dilation; glyceryl trinitrate; high-resolution ultrasound; wall tracking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Playford, DA Univ Western Australia, RPH, Dept Med, Perth, WA 6001, Australia Univ Western Australia Perth WA Australia 6001 01, Australia
Citazione:
R.J. Woodman et al., "Improved analysis of brachial artery ultrasound using a novel edge-detection software system", J APP PHYSL, 91(2), 2001, pp. 929-937

Abstract

Brachial artery ultrasound is commonly employed for noninvasive assessmentof endothelial function. However, analysis is observer dependent and susceptible to errors. We describe studies on a computerized edge-detection and wall-tracking software program to allow more accurate and reproducible measurement. In study 1, three purpose-built Perspex phantom arteries, 3.00, 4.00, and 6.00 mm in diameter, were measured with the software. There was a mean bias of 11 mum (P < 0.001 at each level) between known and measured values; the mean resolving power of the software was estimated as 8.3 <mu>m. In study 2, the mean intraobserver coefficient of variation of repeated measures of flow-mediated dilation (FMD) using the software (6.7%) was significantly lower than that for traditional manual measurements using the intima-lumen interfaces (24.8%, P < 0.05) and intima-media interfaces (32.5%, P < 0.05). In study 3, 24 healthy volunteers underwent repeat testing twice within 1 wk; the coefficients of variation for between-visit reproducibility of FMD and response to glyceryl trinitrate using the software were 14.7 and 17.6%, respectively. Assuming 80% power and an a of 0.05, eight subjects with matched controls would be required, in a parallel designed study, to detect an absolute 2.5% change in FMD. In summary, we have developed a semiautomated computerized vascular ultrasound analysis system that will improve the power of clinical intervention studies to detect small changes in arterial diameter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:38:50