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Titolo:
Chronic airway infection leads to angiogenesis in the pulmonary circulation
Autore:
Hopkins, N; Cadogan, E; Giles, S; McLoughlin, P;
Indirizzi:
Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Human Anat & Physiol, Dublin 2, Ireland Univ Coll Dublin Dublin Ireland 2 uman Anat & Physiol, Dublin 2, Ireland
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 919 - 928
SICI:
8750-7587(200108)91:2<919:CAILTA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATHOLOGICAL RESEARCH; CHRONIC INFLAMMATION; NITRIC-OXIDE; LUNG; MORPHOMETRY; ARTERIES; DISEASE; VASCULATURE; PNEUMONIA; DIAGNOSIS;
Keywords:
Pseudomonas aeruginosa; isolated-perfused lungs; stereology; pulmonary hypertension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: McLoughlin, P Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dept Human Anat & Physiol, Earlsfort Terrace, Dublin 2, Ireland Univ Coll Dublin Earlsfort Terrace Dublin Ireland 2 Ireland
Citazione:
N. Hopkins et al., "Chronic airway infection leads to angiogenesis in the pulmonary circulation", J APP PHYSL, 91(2), 2001, pp. 919-928

Abstract

In both pulmonary and systemic hypertension, the walls of the arteriolar vessels are thickened and the lumen size is reduced, leading to increased total vascular resistance. It has been reported previously that chronic airway infection and inflammation lead to increased wall thickness in the pulmonary vasculature, without the development of pulmonary hypertension. The aimof the present study was to examine quantitatively the remodeling of intra-acinar blood vessels in chronically infected rat lungs. Adult rats were anesthetized and inoculated intratracheally with Pseudomonas aeruginosa (n = 10) incorporated into agar beads to induce chronic airway infection. Control groups included rats inoculated with sterile agar beads (n = 8) and rats that were not inoculated (n = 6). Chronic infection caused vascular wall thickening without reduction in mean lumen radius. Furthermore, chronic infection led to increased total length of intra-acinar vessels and increased numbers of branch points, demonstrating that angiogenesis had occurred. Preservation of lumen size and formation of new parallel pathways in the vasculature of chronically infected lungs account for the maintenance of normal PVR despite vessel wall remodeling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 19:01:49