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Titolo:
Effect of L-NAME on oxygen uptake kinetics during heavy-intensity exercisein the horse
Autore:
Kindig, CA; McDonough, P; Erickson, HH; Poole, DC;
Indirizzi:
Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA Kansas State Univ Manhattan KS USA 66506 Physiol, Manhattan, KS 66506 USA Kansas State Univ, Dept Kinesiol, Manhattan, KS 66506 USA Kansas State Univ Manhattan KS USA 66506 inesiol, Manhattan, KS 66506 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 891 - 896
SICI:
8750-7587(200108)91:2<891:EOLOOU>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VO(2) ON-KINETICS; HUMAN SKELETAL-MUSCLE; SITU CANINE MUSCLE; NITRIC-OXIDE; BLOOD-FLOW; (V)OVER-DOT-O-2 KINETICS; SYNTHASE INHIBITION; O-2 DELIVERY; CONSUMPTION; ONSET;
Keywords:
nitric oxide; nitric oxide synthase inhibition; oxygen uptake slow component; oxygen deficit; nitro-L-arginine methyl ester;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Poole, DC Kansas State Univ, Dept Anat & Physiol, 1600 Denison Ave,Rm 228,Manhattan, KS 66506 USA Kansas State Univ 1600 Denison Ave,Rm 228 Manhattan KS USA 66506
Citazione:
C.A. Kindig et al., "Effect of L-NAME on oxygen uptake kinetics during heavy-intensity exercisein the horse", J APP PHYSL, 91(2), 2001, pp. 891-896

Abstract

There is evidence that oxidative enzyme inertia plays a major role in limiting/setting the O-2 uptake ((V) over dot (O2)) response at the transition to higher metabolic rates and also that nitric oxide (NO) competitively inhibits (V) over dot (O2) within the electron transport chain. To investigatewhether NO is important in setting the dynamic response of (V) over dot (O2) at the onset of high-intensity (heavy-domain) running in horses, five geldings were run on a treadmill across speed transitions from 3 m/s to speeds corresponding to 80% of peak (V) over dot (O2) with and without nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor (20 mg/kg; order randomized). L-NAME did not alter (both P > 0.05) baseline (3 m/s, 15.4 +/- 0.3 and 16.2 +/- 0.5 1/min for control and L-NAME, respectively) or end-exercise (V) over dot (O2) (56.9 +/- 5.1 and 55.2 +/- 5.8 1/min for control andL-NAME, respectively). However, in the L-NAME trial, the primary on-kinetic response was significantly (P < 0.05) faster (i.e., reduced time constant, 27.0 +/- 2.7 and 18.7 +/- 3.0 s for control and L-NAME, respectively), despite no change in the gain of (V) over dot (O2) (P > 0.05). The faster on-kinetic response was confirmed independent of modeling by reduced time to 50, 63, and 75% of overall (V) over dot (O2) response (all P > 0.05). In addition, onset of the (V) over dot (O2) slow component occurred earlier (124.6 +/- 11.2 and 65.0 +/- 6.6 s for control and L-NAME, respectively), and the magnitude of the O-2 deficit was attenuated (both P < 0.05) in the L-NAMEcompared with the control trial. Acceleration of the (V) over dot (O2) kinetics by L-NAME suggests that NO inhibition of mitochondrial (V) over dot (O2) may contribute, in part, to the intrinsic metabolic inertia evidenced at the transition to higher metabolic rates in the horse.

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Documento generato il 20/01/20 alle ore 07:56:27