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Titolo:
Frequency characteristics of lung tissue strip during passive stretch and induced pneumoconstriction
Autore:
Romero, PV; Zin, WA; Lopez-Aguilar, J;
Indirizzi:
Ciutat Sanitaria Univ Bellvitge, Dept Pneumol, Lab Expt Pneumol, Barcelona08907, Spain Ciutat Sanitaria Univ Bellvitge Barcelona Spain 08907 celona08907, Spain Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Physiol Resp Lab, BR-21949900 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-21949900 BCeiro, Brazil
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 882 - 890
SICI:
8750-7587(200108)91:2<882:FCOLTS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAY SMOOTH-MUSCLE; INDUCED CONSTRICTION; MECHANICAL CONTRIBUTIONS; CONTRACTILE STIMULATION; INTERSTITIAL-CELLS; PARENCHYMAL STRIPS; DYNAMIC PROPERTIES; INPUT IMPEDANCE; FIBER NETWORK; 1/F NOISE;
Keywords:
tissue mechanics; multifrequency oscillation; histamine; guinea pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Romero, PV Hosp Univ Bellvitge, Serv Pneumol, C Feixa Llarga S-N, Lhospitalet De Llobregat 08907, Spain Hosp Univ Bellvitge C Feixa Llarga S-N Lhospitalet De Llobregat Spain 08907
Citazione:
P.V. Romero et al., "Frequency characteristics of lung tissue strip during passive stretch and induced pneumoconstriction", J APP PHYSL, 91(2), 2001, pp. 882-890

Abstract

To investigate the frequency-dependent changes of lung tissue mechanics during pneumoconstriction, we studied guinea pig subpleural lung strips submitted to a multisinusoidal deformation composed of five equal-amplitude discrete frequencies ranging between 0.2 and 3.1 Hz. Strips were submitted to graded step stretch changes (SS) and to graded histamine stimulation (HS) inorgan bath. Elastance, resistance, and hysteresivity were calculated at each frequency. The model accounting for the relationship between the complexYoung's modulus and the angular frequency showed that the constant-phase hypothesis was satisfied in SS condition. However, HS modified all parameters in the model, and the constant-phase hypothesis could be rejected for HS of 10(-5) and 10(-3) M. The hysteresivity time course changed with angular frequency, but differently in the HS and SS conditions. Our results agree with a serial disposition of the connective matrix and contractile system inlung tissue. We conclude that pneumoconstriction induced significant structural changes at the level of the connective matrix.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 11:44:46