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Titolo:
Mechanical ventilation of isolated septic rat lungs: effects on surfactantand inflammatory cytokines
Autore:
Nakamura, T; Malloy, J; McCaig, L; Yao, LJ; Joseph, M; Lewis, J; Veldhuizen, R;
Indirizzi:
Univ Western Ontario, St Josephs Hlth Ctr, Lawson Hlth Res Inst, Dept Physiol, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, St Josephs Hlth Ctr, Lawson Hlth Res Inst, Dept Med,London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 ,London, ON N6A 4V2, Canada Univ Western Ontario, St Josephs Hlth Ctr, Lawson Hlth Res Inst, Dept Pathol, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 811 - 820
SICI:
8750-7587(200108)91:2<811:MVOISR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; TUMOR-NECROSIS-FACTOR; RANDOMIZED CONTROLLED TRIAL; PULMONARY SURFACTANT; INJURY; SHOCK; SYSTEM; SEPSIS;
Keywords:
cecal ligation and perforation; sepsis; pulmonary surfactant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Veldhuizen, R Univ Western Ontario, St Josephs Hlth Ctr, Lawson Hlth Res Inst, Dept Physiol, Rm G454,268 Grosvenor St, London, ON N6A 4V2, Canada Univ Western Ontario Rm G454,268 Grosvenor St London ON Canada N6A 4V2
Citazione:
T. Nakamura et al., "Mechanical ventilation of isolated septic rat lungs: effects on surfactantand inflammatory cytokines", J APP PHYSL, 91(2), 2001, pp. 811-820

Abstract

The effects of mechanical ventilation (MV) on the surfactant system and cytokine secretion were studied in isolated septic rat lungs. At 23 h after sham surgery or induction of sepsis by cecal ligation and perforation (CLP),lungs were excised and randomized to one of three groups: 1) a nonventilated group, 2) a group subjected to 1 h of noninjurious MV (tidal volume = 10ml/kg, positive end-expiratory pressure = 3 cmH(2)O), or 3) a group subjected to 1 h of injurious MV (tidal volume = 20 ml/kg, positive end-expiratory pressure = 0 cmH2O). Nonventilated sham and CLP lungs had similar compliance, normal lung morphology, surfactant, and cytokine concentrations. Injurious ventilation decreased compliance, altered surfactant, increased cytokines, and induced morphological changes compared with nonventilation in shamand CLP lungs. In these lungs, the surfactant system was similar in sham and CLP lungs; however, tumor necrosis factor-alpha and interleukin-6 levelswere significantly higher in CLP lungs. We conclude that injurious ventilation altered surfactant independent of sepsis and that the CLP lungs were predisposed to the secretion of larger amounts of cytokines because of ventilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:20:24