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Titolo:
Simulated microgravity upregulates an endothelial vasoconstrictor prostaglandin
Autore:
Sangha, DS; Han, S; Purdy, RE;
Indirizzi:
Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 ept Pharmacol, Irvine, CA 92697 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 789 - 796
SICI:
8750-7587(200108)91:2<789:SMUAEV>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASES; VASCULAR ENDOTHELIUM; HINDLIMB SUSPENSION; BLOOD-FLOW; RAT AORTA; MUSCLE; CELLS; MECHANISMS; PRESSURE; EXERCISE;
Keywords:
cyclooxygenase; endothelium; hindlimb unweighting; nitric oxide; vasoconstriction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Purdy, RE Univ Calif Irvine, Coll Med, Dept Pharmacol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 col, Irvine, CA 92697 USA
Citazione:
D.S. Sangha et al., "Simulated microgravity upregulates an endothelial vasoconstrictor prostaglandin", J APP PHYSL, 91(2), 2001, pp. 789-796

Abstract

Endothelial nitric oxide contributes to the vascular hyporesponsiveness tonorepinephrine (NE) observed in carotid arteries from rats exposed to simulated microgravity. The goal of the present study was to determine whether a cyclooxygenase product of arachidonic acid also influences vascular responsiveness in this setting. Microgravity was simulated in rats by hindlimb unweighting (HU). After 20 days of HU, carotid arteries were isolated from control and HU-treated rats, and vascular rings were mounted in tissue bathsfor the measurement of isometric contraction. Two cyclooxygenase inhibitors, indomethacin and ibuprofen, and the selective thromboxane A(2) prostanoid-receptor antagonist, SQ-29548, had no effect on the contraction to NE in control vessels but markedly reduced contraction to NE in HU vessels. When the endothelium was removed, indomethacin no longer had any effect on the NE-induced contraction in HU vessels. In endothelium-intact vessels in the presence of indomethacin, the addition of the nitric oxide synthase inhibitor, N-G-L-nitro-arginine methyl ester, to the medium bathing HU vessels increased the contraction to NE to the level of that of the control vessels. These results indicate that HU treatment induced two endothelial changes in carotid artery that opposed each other. Nitric oxide activity was increased and was responsible for the vascular hyporesponsiveness to NE. The activityof a vasoconstrictor prostaglandin was also increased, and attenuated the vasodilating effect of nitric oxide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:40:13