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Titolo:
TGF-beta(1) and prepro-ANP mRNAs are differentially regulated in exercise-induced cardiac hypertrophy
Autore:
Calderone, A; Murphy, RJL; Lavoie, J; Colombo, F; Beliveau, L;
Indirizzi:
Inst Cardiol Montreal, Ctr Rech, Montreal, PQ H1T 1C8, Canada Inst CardiolMontreal Montreal PQ Canada H1T 1C8 real, PQ H1T 1C8, Canada Univ Montreal, Dept Physiol, Montreal, PQ H1T 1C8, Canada Univ Montreal Montreal PQ Canada H1T 1C8 ol, Montreal, PQ H1T 1C8, Canada Univ Montreal, Dept Kinesiol, Montreal, PQ H1T 1C8, Canada Univ Montreal Montreal PQ Canada H1T 1C8 ol, Montreal, PQ H1T 1C8, Canada Acadia Univ, Sch Recreat Management & Kinesiol, Acadia, NS, Canada Acadia Univ Acadia NS Canada t Management & Kinesiol, Acadia, NS, Canada
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 771 - 776
SICI:
8750-7587(200108)91:2<771:TAPMAD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; RAT; GROWTH; MYOCYTES; ADAPTATIONS; MYOCARDIUM; MORPHOLOGY; COLLAGEN; MUSCLE; MYOSIN;
Keywords:
voluntary exercise (training); physiological cardiac hypertrophy; collagen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Calderone, A Inst Cardiol Montreal, Ctr Rech, 5000 Rue Belanger Est, Montreal, PQ H1T 1C8, Canada Inst Cardiol Montreal 5000 Rue Belanger Est Montreal PQ Canada H1T 1C8
Citazione:
A. Calderone et al., "TGF-beta(1) and prepro-ANP mRNAs are differentially regulated in exercise-induced cardiac hypertrophy", J APP PHYSL, 91(2), 2001, pp. 771-776

Abstract

The induction of transforming growth factor (TGF)-beta and prepro- atrial natriuretic peptide (ANP) mRNAs represent hallmark features of pathologicalcardiac hypertrophy. The present study examined whether this pattern of mRNA expression was conserved in a physiological model of cardiac hypertrophy. To address this thesis, female Sprague-Dawley rats were individually housed and permitted to run freely. Voluntary exercise for 3 and 6 wk resulted in biventricular hypertrophy and increased cytochrome c oxidase activity inthe triceps muscle. In the hypertrophied left ventricle, the steady-state mRNA level of the cardiac fetal gene prepro- ANP and the extracellular matrix proteins preprocollagen-alpha (1) and fibronectin were similar in exercise-trained and sedentary rats. By contrast, an increased expression of TGF-beta (1) mRNA was observed, whereas TGF-beta (3) mRNA level was unchanged in the hypertrophied left ventricle of exercise-trained compared with sedentary rats. These data highlight a heterogeneity in the regulation of TGF-beta isoforms, and the increased expression of ventricular TGF-beta (1) mRNA in physiological cardiac hypertrophy may contribute to myocardial remodeling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:31:39