Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities
Autore:
Sakai, H; Ingenito, EP; Mora, R; Abbay, S; Cavalcante, FSA; Lutchen, KR; Suki, B;
Indirizzi:
Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA Boston Univ Boston MAUSA 02215 v, Dept Biomed Engn, Boston, MA 02215 USA Brigham & Womens Hosp, Div Pulm & Crit Care Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Care Med, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 737 - 747
SICI:
8750-7587(200108)91:2<737:HOTLAT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREQUENCY-DEPENDENCE; PULMONARY RESISTANCE; CHEST-WALL; DOG LUNGS; VOLUME; AIRWAY; MECHANICS; CONSTRICTION; IMPEDANCE; PRESSURE;
Keywords:
tissue resistance; tissue elastance; configuration; compartmental behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Suki, B Boston Univ, Dept Biomed Engn, 44 Cummington St, Boston, MA 02215 USA Boston Univ 44 Cummington St Boston MA USA 02215 ton, MA 02215 USA
Citazione:
H. Sakai et al., "Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities", J APP PHYSL, 91(2), 2001, pp. 737-747

Abstract

We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance andairway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distributionof Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequenciesand operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. Wefound that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is primarily determined by lung connective tissue, and its elevated estimates from impedance data in the CC and OC conditions are a consequence of compartment-like heterogeneity being greater in CC and OC conditions than in the IL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:21:49