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Titolo:
Multiple firing of single muscle vasoconstrictor neurons during cardiac dysrhythmias in human heart failure
Autore:
Elam, M; Macefield, V;
Indirizzi:
Sahlgrens Univ Hosp, Inst Clin Neurosci, Dept Clin Neurophysiol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden Prince Wales Res Inst, Sydney, NSW 2031, Australia Prince Wales Res Inst Sydney NSW Australia 2031 dney, NSW 2031, Australia
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 717 - 724
SICI:
8750-7587(200108)91:2<717:MFOSMV>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; MYOCARDIAL-INFARCTION; BAROREFLEX CONTROL; NEURAL ACTIVITY; OUTFLOW; ACTIVATION; RESPONSES; SUDDEN; BEATS; DEATH;
Keywords:
microneurography; single unit; sympathoexcitation; ectopic beats; tachyarrhythmia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Elam, M Sahlgrens Univ Hosp, Inst Clin Neurosci, Dept Clin Neurophysiol, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 Gothenburg, Sweden
Citazione:
M. Elam e V. Macefield, "Multiple firing of single muscle vasoconstrictor neurons during cardiac dysrhythmias in human heart failure", J APP PHYSL, 91(2), 2001, pp. 717-724

Abstract

Single vasoconstrictor nerve fibers in humans normally fire only once but have the capacity to fire as many as eight times, per cardiac interval. Ourlaboratory recently demonstrated that the mean firing frequency of individual vasoconstrictor fibers is more than doubled in the sympathoexcitation associated with congestive heart failure (Macefield VG, Rundqvist B, Sverrisdottir YB, Wallin BG, and Elam M. Circulation 100: 1708-1713, 1999). However, the propensity to fire only once per cardiac interval was retained. In the present retrospective study, we tested the hypothesis that vasoconstrictor fibers fire more than once per cardiac interval in response to transientsympathoexcitatory stimuli, providing one mechanism for further increase of an already augmented sympathetic discharge. Six patients with congestive heart failure (New York Heart Association functional class II-IV; left ventricular ejection range 13-37%, average 22%) were studied at rest and duringpremature ectopic heartbeats. Analyzed for a total of 60 premature beats, the average firing probability of 10 vasoconstrictor fibers increased from 61 to 80% in the prolonged cardiac interval (i.e., reduced diastolic pressure) after premature beats. The incidence of multiple within-burst firing increased markedly, with two spikes being more common than one. Our results illustrate two different mechanisms (increases in firing probability and multiple within-burst firing), and indirectly indicate a third mechanism (recruitment of previously silent fibers), for acute sympathoexcitatory responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:24:52