Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Ventilatory long-term facilitation in unanesthetized rats
Autore:
Olson, EB; Bohne, CJ; Dwinell, MR; Podolsky, A; Vidruk, EH; Fuller, DD; Powell, FL; Mitchel, GS;
Indirizzi:
Univ Wisconsin, Sch Med, Dept Prevent Med, John Rankin Lab Pulm Med, Madison, WI 53705 USA Univ Wisconsin Madison WI USA 53705 n Lab Pulm Med, Madison, WI 53705 USA Univ Wisconsin, Sch Vet Med, Dept Comparat Biosci, Madison, WI 53705 USA Univ Wisconsin Madison WI USA 53705 omparat Biosci, Madison, WI 53705 USA Univ Calif San Diego, Dept Med, Div Physiol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 hysiol, La Jolla, CA 92093 USA Univ Calif San Diego, White Mt Res Stn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 es Stn, La Jolla, CA 92093 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 709 - 716
SICI:
8750-7587(200108)91:2<709:VLFIUR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHRENIC MOTOR OUTPUT; PROLONGED STIMULATION; CHRONIC HYPOXIA; AWAKE RATS; RESPONSES; RESPIRATION; SEROTONIN; INTACT; GOATS; CATS;
Keywords:
ventilation; plasticity; intermittent hypoxia; hypoxia; respiratory control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Olson, EB Univ Wisconsin, Sch Med, Dept Prevent Med, John Rankin Lab Pulm Med, 504 NWalnut St, Madison, WI 53705 USA Univ Wisconsin 504 N Walnut St Madison WI USA 53705 WI 53705 USA
Citazione:
E.B. Olson et al., "Ventilatory long-term facilitation in unanesthetized rats", J APP PHYSL, 91(2), 2001, pp. 709-716

Abstract

We tested the hypothesis that unanesthetized rats exhibit ventilatory longterm facilitation (LTF) after intermittent, but not continuous, hypoxia. Minute ventilation (VE) and carbon dioxide production (V(over dot)CO2) were measured in unanesthetized, unrestrained male Sprague-Dawley rats via barometric plethysmography before, during, and after exposure to continuous or intermittent hypoxia. Hypoxia was either isocapnic [inspired O-2 fraction (FIO2) = 0.08-0.09 and inspired CO2 fraction (FICO2) = 0.04] or poikilocapnic (FIO2 = 0.11 and FICO2. = 0.00). Sixty minutes after intermittent hypoxia, V(over dot)E or V(over dot)E/VCO2 was significantly greater than baseline in both isocapnic and poikilocapnic conditions. In contrast, 60 min after continuous hypoxia, V(over dot)E and V(over dot)E/VCO2 were not significantlydifferent from baseline values. These data demonstrate ventilatory LTF after intermittent hypoxia in unanesthetized rats. Ventilatory LTF appeared similar in its magnitude (after accounting for CO2 feedback), time course, and dependence on intermittent hypoxia to phrenic LTF previously observed in anesthetized, vagotomized, paralyzed rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 21:19:55