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Titolo:
Reduced lipoprotein lipase activity in postural skeletal muscle during aging
Autore:
Bey, L; Areiqat, E; Sano, A; Hamilton, MT;
Indirizzi:
Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA Univ Missouri Columbia MO USA 65211 ovasc Res Ctr, Columbia, MO 65211 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 687 - 692
SICI:
8750-7587(200108)91:2<687:RLLAIP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADIPOSE-TISSUE; LIPID-METABOLISM; FISCHER-344 RATS; TRANSGENIC MICE; OLD RATS; AGE; YOUNG; HYPERTRIGLYCERIDEMIA; HYPERCHOLESTEROLEMIA; OVEREXPRESSION;
Keywords:
exercise; physical inactivity; very-low-density lipoprotein; lipid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hamilton, MT Univ Missouri, Dalton Cardiovasc Res Ctr, Vet Med Bldg,1600 ERollins, Columbia, MO 65211 USA Univ Missouri Vet Med Bldg,1600 E Rollins Columbia MO USA 65211
Citazione:
L. Bey et al., "Reduced lipoprotein lipase activity in postural skeletal muscle during aging", J APP PHYSL, 91(2), 2001, pp. 687-692

Abstract

Lipoprotein lipase (LPL) is a key enzyme for fatty acid and lipoprotein metabolism in muscle. However, the effect of aging on LPL regulation in skeletal muscle is unknown. We report the effect of aging on LPL regulation in the soleus (red oxidative postural) muscle and the tibialis anterior (white glycolytic non-weight-bearing) muscle in 4- and 24-mo-old Fischer 344 rats and 18- and 31-mo-old Fischer 344 X Brown-Norway F1 (F-344 X BN F1) rats. Total and heparin-releasable LPL (HR-LPL) activities were decreased 38% (P <0.01) and 52% (P < 0.05), respectively, in the soleus muscle of the older Fischer 344 rats. There was a 32% reduction (P < 0.05) of total LPL proteinmass in the soleus muscle with aging. The results were confirmed in another strain. A decrease of total LPL activity (-50%, P < 0.05) was also found in the soleus muscle between 18- and 31-mo-old F-344 X BN F1 rats. LPL mRNAconcentration in the soleus muscle was not different between ages. Total LPL protein mass was reduced by 46% (P < 0.05) in the soleus muscle of the 31-mo-old F-344 X BN F1 rats. In the tibialis anterior muscle, neither LPL activity nor mRNA concentration was affected by age in either strain. In conclusion, LPL regulation in a non- weight-bearing muscle was not affected byaging. However, there was a pronounced reduction in LPL activity and LPL protein mass in postural muscle with aging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:10:12