Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cardiac atrophy after bed rest and spaceflight
Autore:
Perhonen, MA; Franco, F; Lane, LD; Buckey, JC; Blomqvist, CG; Zerwekh, JE; Peshock, RM; Weatherall, PT; Levine, BD;
Indirizzi:
Presbyterian Hosp, Inst Exercise & Environm Med, Dallas, TX 75231 USA Presbyterian Hosp Dallas TX USA 75231 Environm Med, Dallas, TX 75231 USA Univ Texas, SW Med Ctr, Dept Internal Med & Radiol, Dallas, TX 75231 USA Univ Texas Dallas TX USA 75231 nternal Med & Radiol, Dallas, TX 75231 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 645 - 653
SICI:
8750-7587(200108)91:2<645:CAABRA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR MASS; RAT-HEART; ORTHOSTATIC INTOLERANCE; MITRAL REGURGITATION; MYOCARDIAL MASS; HYPERTROPHY; LOAD; HYPERTENSION; MICROGRAVITY; EXERCISE;
Keywords:
magnetic resonance imaging; left ventricular mass; left ventricular end-diastolic volume; right ventricular mass; right ventricular end-diastolic volume;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Levine, BD Presbyterian Hosp, Inst Exercise & Environm Med, 7232 Greenville Ave,Suite435, Dallas, TX 75231 USA Presbyterian Hosp 7232 Greenville Ave,Suite 435 Dallas TX USA 75231
Citazione:
M.A. Perhonen et al., "Cardiac atrophy after bed rest and spaceflight", J APP PHYSL, 91(2), 2001, pp. 645-653

Abstract

Cardiac muscle adapts well to changes in loading conditions. For example, left ventricular (LV) hypertrophy may be induced physiologically (via exercise training) or pathologically (via hypertension or valvular heart disease). If hypertension is treated, LV hypertrophy regresses, suggesting a sensitivity to LV work. However, whether physical inactivity in nonathletic populations causes adaptive changes in LV mass or even frank atrophy is not clear. We exposed previously sedentary men to 6 (n = 5) and 12 (n = 3) wk of horizontal bed rest. LV and right ventricular (RV) mass and end-diastolic volume were measured using cine magnetic resonance imaging (MRI) at 2, 6, and12 wk of bed rest; five healthy men were also studied before and after at least 6 wk of routine daily activities as controls. In addition, four astronauts were exposed to the complete elimination of hydrostatic gradients during a spaceflight of 10 days. During bed rest, LV mass decreased by 8.0 +/-2.2% (P = 0.005) after 6 wk with an additional atrophy of 7.6 +/- 2.3% in the subjects who remained in bed for 12 wk; there was no change in LV mass for the control subjects (153.0 +/- 12.2 vs. 153.4 +/- 12.1 g, P = 0.81). Mean wall thickness decreased (4 +/- 2.5%, P = 0.01) after 6 wk of bed rest associated with the decrease in LV mass, suggesting a physiological remodeling with respect to altered load. LV end-diastolic volume decreased by 14 +/- 1.7% (P = 0.002) after 2 wk of bed rest and changed minimally thereafter. After 6 wk of bed rest, RV free wall mass decreased by 10 +/- 2.7% (P = 0.06) and RV end-diastolic volume by 16 +/- 7.9% (P = 0.06). After spaceflight, LV mass decreased by 12 +/- 6.9% (P = 0.07). In conclusion, cardiac atrophy occurs during prolonged (6 wk) horizontal bed rest and may also occur after short-term spaceflight. We suggest that cardiac atrophy is due to a physiological adaptation to reduced myocardial load and work in real or simulated microgravity and demonstrates the plasticity of cardiac muscle under different loading conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:59:43