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Titolo:
Women at altitude: short-term exposure to hypoxia and/or alpha(1)-adrenergic blockade reduces insulin sensitivity
Autore:
Braun, B; Rock, PB; Zamudio, S; Wolfel, GE; Mazzeo, RS; Muza, SR; Fulco, CS; Moore, LG; Butterfield, GE;
Indirizzi:
Vet Affairs Hlth Care Syst, Ctr Geriatr Res Educ & Clin, Palo Alto, CA 94304 USA Vet Affairs Hlth Care Syst Palo Alto CA USA 94304 Palo Alto, CA 94304 USA Stanford Univ, Sch Med, Dept Endocrinol Gerontol & Metab, Palo Alto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 tol & Metab, Palo Alto, CA 94304 USA USA, Environm Med Res Inst, Div Thermal & Mt, Natick, MA 01460 USA USA Natick MA USA 01460 Res Inst, Div Thermal & Mt, Natick, MA 01460 USA Univ Colorado, Hlth Sci Ctr, Denver, CO 80262 USA Univ Colorado Denver COUSA 80262 ado, Hlth Sci Ctr, Denver, CO 80262 USA Univ Colorado, Dept Kinesiol & Appl Physiol, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 & Appl Physiol, Boulder, CO 80309 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 623 - 631
SICI:
8750-7587(200108)91:2<623:WAASET>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMEOSTASIS MODEL ASSESSMENT; GLUCOSE-TOLERANCE; CELL FUNCTION; EXERCISE; METABOLISM; RESISTANCE; RESPONSES; 4,300-M; INVIVO; RATS;
Keywords:
homeostatic model; glucose tolerance; insulin resistance; epinephrine; prazosin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Braun, B Univ Massachusetts, Dept Exercise Sci, 106 Totman Bldg, Amherst, MA 01003 USA Univ Massachusetts 106 Totman Bldg Amherst MA USA 01003 01003 USA
Citazione:
B. Braun et al., "Women at altitude: short-term exposure to hypoxia and/or alpha(1)-adrenergic blockade reduces insulin sensitivity", J APP PHYSL, 91(2), 2001, pp. 623-631

Abstract

After short-term exposure to high altitude (HA), men appear to be less sensitive to insulin than at sea level (SL). We hypothesized that the same would be true in women, that reduced insulin sensitivity would be directly related to the rise in plasma epinephrine concentrations at altitude, and thatthe addition of alpha -adrenergic blockade would potentiate the reduction. To test the hypotheses, 12 women consumed a high-carbohydrate meal at SL and after 16 h at simulated 4,300-m elevation (HA). Subjects were studied twice at each elevation: once with prazosin (Prz), an alpha (1)-adrenergic antagonist, and once with placebo (Pla). Mathematical models were used to assess insulin resistance based on fasting [homeostasis model assessment of insulin resistance (HOMA-IR)] and postprandial [composite model insulin sensitivity index (C-ISI)] glucose and insulin concentrations. Relative to SL-Pla (HOMA-IR: 1.86 +/- 0.35), insulin resistance was greater in HA-Pla (3.00 /- 0.45; P < 0.05), SL-Prz (3.46 +/- 0.51; P < 0.01), and HA-Prz (2.82 +/-0.43; P < 0.05). Insulin sensitivity was reduced in HA-Pla (C-ISI: 4.41 +/- 1.03; P < 0.01), SL-Prz (5.73 +/- 1.01; P < 0.05), and HA-Prz (4.18 +/- 0.99; P < 0.01) relative to SL-Pla (8.02 +/- 0.92). Plasma epinephrine was significantly elevated in HA-Pla (0.57 +/- 0.08 ng/ml; P < 0.01), SL-Prz (0.42 +/- 0.07; P < 0.05), and HA-Prz (0.82 +/- 0.07; P < 0.01) relative to SL-Pla (0.28 +/- 0.04), but correlations with HOMA- IR, HOMA-<beta>-cell function, and C-ISI were weak. In women, short-term exposure to simulated HA reduced insulin sensitivity compared with SL. The change does not appear to be directly mediated by a concurrent rise in plasma epinephrine concentrations.

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Documento generato il 20/01/21 alle ore 10:32:23