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Titolo:
Dopamine-1 receptor stimulation attenuates the vasoconstrictive response to gut ischemia
Autore:
Guzman, JA; Rosado, AE; Kruse, JA;
Indirizzi:
Wayne State Univ, Sch Med, Div Pulm Crit Care & Sleep Med, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 & Sleep Med, Detroit, MI 48201 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 596 - 602
SICI:
8750-7587(200108)91:2<596:DRSATV>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC INTRAMUCOSAL PH; LOW-DOSE DOPAMINE; CRITICALLY ILL PATIENTS; SYSTEM ORGAN FAILURE; HEMORRHAGIC-SHOCK; TISSUE OXYGENATION; SEPSIS SYNDROME; SEPTIC SHOCK; TONOMETRY; PCO2;
Keywords:
fenoldopam; hemorrhage; splanchnic perfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Guzman, JA Detroit Receiving Hosp, 4201 St Antoine Blvd, Detroit, MI 48201USA Detroit Receiving Hosp 4201 St Antoine Blvd Detroit MI USA 48201
Citazione:
J.A. Guzman et al., "Dopamine-1 receptor stimulation attenuates the vasoconstrictive response to gut ischemia", J APP PHYSL, 91(2), 2001, pp. 596-602

Abstract

The effects of fenoldopam, a dopamine-1 (DA-1) receptor agonist, were studied in two groups of anesthetized dogs before and after inducion of splanchnic ischemia by way of hemorrhage. During the first portion of the experiment, both groups received fenoldopam (1.5 mug.kg (-1).min(-1)) for 45 min followed by a 45-min washout. During the second portion, hemorrhage (10 ml/kg) was induced, followed by no intervention in group I (controls) and restarting of the fenoldopam infusion in group II. Prehemorrhage, fenoldopam increased composite portal blood flow by 33% (P < 0.01). After hemorrhage-induced splanchnic ischemia, fenoldopam restored portal vein blood flow to near baseline, maintained the splanchnic fraction of cardiac output, and attenuated the rise in gut mucosal PCO2. DA-1 receptor stimulation increased portal blood flow and redistributed blood flow away from the serosal layer in favor of the mucosa during basal conditions and after hemorrhage, suggesting a more concentrated distribution of splanchnic DA-1 receptors within the mucosal layer vasculature. Fenoldopam maintained splanchnic blood flow duringhypoperfusion and attenuated the splanchnic vasoconstrictive response to hemorrhage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 20:03:23