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Titolo:
Adenosine A1 receptors mediate plasma exudation from the oral mucosa
Autore:
Rubinstein, I; Chandilawa, R; Dagar, S; Hong, D; Gao, XP;
Indirizzi:
Univ Illinois, Dept Med, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 inois, Dept Med, Chicago, IL 60612 USA Univ Illinois, Dept Pharmaceut & Pharmacodynam, Chicago, IL 60612 USA UnivIllinois Chicago IL USA 60612 & Pharmacodynam, Chicago, IL 60612 USA Vet Affairs Chicago Hlth Care Syst, W Side Div, Chicago, IL 60612 USA Vet Affairs Chicago Hlth Care Syst Chicago IL USA 60612 ago, IL 60612 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 91, anno: 2001,
pagine: 552 - 560
SICI:
8750-7587(200108)91:2<552:AARMPE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAMSTER-CHEEK POUCH; NITRIC-OXIDE; INDUCED INCREASES; EDEMA FORMATION; IN-VIVO; PERMEABILITY; MECHANISMS; BRADYKININ; INVIVO; MACROMOLECULES;
Keywords:
microcirculation; venules; inflammation; intravital microscopy; adenosine analogs; adenosine receptor antagonists;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Rubinstein, I Univ Illinois, Dept Med, M-C 787,840 S Wood St, Chicago, IL 60612 USA Univ Illinois M-C 787,840 S Wood St Chicago IL USA 60612 USA
Citazione:
I. Rubinstein et al., "Adenosine A1 receptors mediate plasma exudation from the oral mucosa", J APP PHYSL, 91(2), 2001, pp. 552-560

Abstract

The purpose of this study was to pharmacologically characterize the adenosine receptor subtype(s) that mediates adenosine-induced increases in macromolecular efflux from the intact hamster cheek pouch. Using intravital microscopy, we found that 1,3-dipropyl-8-(2-amino- 4-chlorophenyl)-xanthine (PACPX), a selective adenosine receptor-1 antagonist, but not 3,7-dimethyl-1-propargyl-xanthine (DMPX), a selective adenosine receptor-2 antagonist, significantly attenuated adenosine-induced leaky site formation and increased clearance of fluorescein isothiocyanate-labeled dextran (molecular mass, 70 kDa) from the intact hamster cheek pouch (P < 0.05). Both compounds had no significant effects on bradykinin-induced responses. Nanomolar concentrations of R(-)-N-6-(2-phenylisopropyl)-adenosine [R(-)-PIA], a selective adenosine A(1) agonist, evoked significant, concentration-dependent increases in macromolecular efflux. This response was significantly attenuated by PACPX but not by DMPX. In contrast, CGS-21680, a selective adenosine A(2) agonist,increased macromolecular efflux but only at micromolar concentrations. This response was significantly attenuated by DMPX but not by PACPX. Suffusionof nitroglycerin had no significant effects on R(-)-PIA- and CGS-21680-induced responses. In addition, suffusion of N-G-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, had no significant effects on adenosine-induced responses. Indomethacin had no significant effects on adenosine-,R(-)- PIA-, and CGS-21680-induced increases in macromolecular efflux. Collectively, these data indicate that adenosine increases macromolecular efflux from the intact hamster cheek pouch by stimulating high-affinity adenosine A1 receptors in a specific, nitric oxide- and prostaglandinin-dependent fashion.

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Documento generato il 22/01/20 alle ore 12:45:10