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Titolo:
Microsatellite and chromosome instability in squamous cell laryngeal carcinoma
Autore:
Sasiadek, M; Stembalska-Kozlowska, A; Smigiel, R; Krecicki, T; Blin, N; Mirghomizadeh, F;
Indirizzi:
Med Univ Wroclaw, Dept Genet, PL-50368 Wroclaw, Poland Med Univ Wroclaw Wroclaw Poland PL-50368 Genet, PL-50368 Wroclaw, Poland Med Univ Wroclaw, Dept Pathophysiol, PL-50368 Wroclaw, Poland Med Univ Wroclaw Wroclaw Poland PL-50368 ysiol, PL-50368 Wroclaw, Poland Med Univ Wroclaw, Dept Otolaryngol, PL-50368 Wroclaw, Poland Med Univ Wroclaw Wroclaw Poland PL-50368 yngol, PL-50368 Wroclaw, Poland Inst Anthropol & Human Genet, Tubingen, Germany Inst Anthropol & Human Genet Tubingen Germany Genet, Tubingen, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 2, volume: 19, anno: 2001,
pagine: 401 - 405
SICI:
1019-6439(200108)19:2<401:MACIIS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECK-CANCER; ALLELIC LOSS; SHORT ARM; HEAD; HETEROZYGOSITY; 8P; CARCINOGENESIS; HYBRIDIZATION; DELETION; TUMORS;
Keywords:
head-and-neck squamous cell carcinoma; loss of heterozygosity; microsatellite instability; bleomycin test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Sasiadek, M Med Univ Wroclaw, Dept Genet, Marcinkowskiego 1, PL-50368 Wroclaw, Poland Med Univ Wroclaw Marcinkowskiego 1 Wroclaw Poland PL-50368 nd
Citazione:
M. Sasiadek et al., "Microsatellite and chromosome instability in squamous cell laryngeal carcinoma", INT J ONCOL, 19(2), 2001, pp. 401-405

Abstract

Head-and neck squamous cell carcinoma (HNSCC) represents almost 5% of all malignancies in Europe. The aetiology of HNSCC is complex, with both genetic and mutagenic factors involved. The aim of the present study was to investigate the loss of heterozygosity (LOH), mainly at tumour suppressor loci (using markers D1S2883, D2S123, D3S1611, D5S346, D7S501, D8S254, TP53, NM23), microsatellite instability (BAT25, 26, 40) and 'hidden chromosome instability' (bleomycin test) in patients with squamous cell larynx cancer. In a group of 20 patients LOH was observed mainly at the loci 3p (64.7%), 8q (71.4%), 17q (M1-30.8%, M2-25%, M3-38.5%). Despite chromosomal instability detected by bleomycin no microsatellite instability was observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 13:08:19