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Titolo:
Effect of cyclic plasma perfusion on apoptosis regulatory proteins in primary tumors of VX2-carcinoma-bearing rabbits
Autore:
Ishiko, O; Sumi, T; Yoshida, H; Hyun, Y; Ogita, S;
Indirizzi:
Osaka City Univ, Sch Med, Dept Obstet & Gynecol, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 ecol, Abeno Ku, Osaka 5458585, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 2, volume: 19, anno: 2001,
pagine: 325 - 329
SICI:
1019-6439(200108)19:2<325:EOCPPO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANEMIA-INDUCING SUBSTANCE; PROGRAMMED CELL-DEATH; BEARING RABBITS; CANCER CACHEXIA; LIPOLYTIC-ACTIVITY; PURIFICATION; MECHANISMS; DISEASE; DNA;
Keywords:
plasma perfusion; Bax; Bcl-2; apoptosis; VX2 carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ishiko, O Osaka City Univ, Sch Med, Dept Obstet & Gynecol, Abeno Ku, 1-4-3Asahimachi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahimachi Osaka Japan 5458585 585, Japan
Citazione:
O. Ishiko et al., "Effect of cyclic plasma perfusion on apoptosis regulatory proteins in primary tumors of VX2-carcinoma-bearing rabbits", INT J ONCOL, 19(2), 2001, pp. 325-329

Abstract

Although the mechanism of cancer cachexia is unknown, in previous studies we reported that cyclic plasma perfusion through non-coated charcoal was effective in preventing cancer cachexia. In the present study we investigatedthe effect of cyclic plasma perfusion on VX2 carcinoma. Sixteen tumor-bearing rabbits were divided into two groups: i) a group subjected to cyclic plasma perfusion (n=8, group PP) and ii) a group subjected to sham-perfusion (n=8, group SP), and changes in body weight, tumor size, and morphological findings were investigated. Body weight loss and tumor growth were significantly suppressed in group PP. The tumor cells in group PP showed apoptosis and a high Bax/Bcl-2 ratio, and the survival rate was significantly higher than in group SP. These results suggest that cyclic plasma perfusion is effective not only in preventing cancer cachexia but in suppressing tumor growth and improving outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 13:49:46