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Titolo:
Hypermethylation of p16(INK4a) and p15(INK4b) genes in non-small cell lungcancer
Autore:
Kurakawa, E; Shimamoto, T; Utsumi, K; Hirano, T; Kato, H; Ohyashiki, K;
Indirizzi:
Tokyo Med Univ, Dept Internal Med 1, Shinjuku Ku, Tokyo 1600023, Japan Tokyo Med Univ Tokyo Japan 1600023 1, Shinjuku Ku, Tokyo 1600023, Japan Tokyo Med Univ, Dept Surg 1, Tokyo 1600023, Japan Tokyo Med Univ Tokyo Japan 1600023 iv, Dept Surg 1, Tokyo 1600023, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF ONCOLOGY
fascicolo: 2, volume: 19, anno: 2001,
pagine: 277 - 281
SICI:
1019-6439(200108)19:2<277:HOPAPG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROSATELLITE ALTERATIONS; PROMOTER METHYLATION; POOR-PROGNOSIS; SERUM DNA; P16; INACTIVATION; PLASMA;
Keywords:
methylation; non-small cell lung cancer; p16(INK4a); p15(INK4b);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Shimamoto, T Tokyo Med Univ, Dept Internal Med 1, Shinjuku Ku, 6-7-1 Nishishinjuku, Tokyo 1600023, Japan Tokyo Med Univ 6-7-1 Nishishinjuku Tokyo Japan 1600023 Japan
Citazione:
E. Kurakawa et al., "Hypermethylation of p16(INK4a) and p15(INK4b) genes in non-small cell lungcancer", INT J ONCOL, 19(2), 2001, pp. 277-281

Abstract

Hypermethylation of CpG island is a common mechanism by which tumor suppressor genes are inactivated. The tumor suppressor genes p16(INK4a) and p15(INK4b) are important components of the cell cycles. We have studied the feasibility of detecting tumor-associated aberrant p16(INK4a) and p15(INK4b) methylation in non-small cell lung cancer (NSCLC) using methylation-specific PCR. We found a high frequency of hypermethylation of the p16(INK4a) gene in 17 of 45 cases of NSCLC. In this study, there was no difference between the clinicopathological features or overall survival of patients with and without p16(INK4a) methylation. On the other hand, p15(INK4b) promoter hypermethylation is rare (5/45) in lung cancer and occurs in association with p16(INK4a) methylation. The overall survival of patients with p15(INK4b) methylation was markedly shortened in this series. We also analyzed cells in bronchial washings, and p16(INK4a) methylation was detected in 4 of 17 cases of NSCLC. Moreover, 1 of 10 plasma samples from patients with NSCLC was positive for p16(INK4a) methylation. Our results suggest a possible prognostic role of p15(INK4b) methylation in NSCLC, and that the detection of aberrantp16(INK4a) methylation in both bronchial washings and plasma may be usefulfor cancer diagnosis.

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Documento generato il 02/04/20 alle ore 12:53:06