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Titolo:
Invasive properties of serous human epithelial ovarian tumors are related to Ets-1, MMP-1 and MMP-9 expression
Autore:
Behrens, P; Rothe, M; Florin, A; Wellmann, A; Wernert, N;
Indirizzi:
Univ Bonn, Inst Pathol, D-53105 Bonn, Germany Univ Bonn Bonn Germany D-53105 Bonn, Inst Pathol, D-53105 Bonn, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 2, volume: 8, anno: 2001,
pagine: 149 - 154
SICI:
1107-3756(200108)8:2<149:IPOSHE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; STAGE-I CARCINOMAS; PLASMINOGEN-ACTIVATOR; MATRIX METALLOPROTEINASES; TRANSCRIPTION FACTOR; GENE FAMILY; BORDERLINE MALIGNANCY; BINDING-SITES; CELL-LINES; KI-RAS;
Keywords:
ovarian cancer; invasion; metalloproteinases; Ets-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Wernert, N Univ Bonn, Inst Pathol, Sigmund Freud Str 25, D-53105 Bonn, Germany Univ Bonn Sigmund Freud Str 25 Bonn Germany D-53105 n, Germany
Citazione:
P. Behrens et al., "Invasive properties of serous human epithelial ovarian tumors are related to Ets-1, MMP-1 and MMP-9 expression", INT J MOL M, 8(2), 2001, pp. 149-154

Abstract

The invasive potential of serous epithelial ovarian tumors is the main factor determining their biological behaviour. In contrast to invasive serous ovarian carcinomas serous borderline tumors generally present without stromal invasion and without or non-invading peritoneal implants. Little is known about the reasons underlying these differences. In the present study we found that two matrix-degrading metalloproteinases, collagenases 1 and 4 (MMPs 1 and 9), as well as the Ets-1 transcription factor are expressed at very Low levels in serous benign cystadenomas, upregulated in the fibroblasticstroma, but not in the epithelium of borderline tumors and most strongly expressed in both stromal and epithelial tumor cells of serous invasive carcinomas. Since expression of Ets-1 and of MMPs 1 and 9 are topographically related, a transcriptional regulation of both proteases by Ets-l is suggested. Upregulation of MMPs 1 and 9 within fibroblastic stromal cells of borderline tumors might be related to matrix remodelling and additional expression of both enzymes by the neoplastic cells of invasive carcinomas could thenallow invasive propagation. The different expression patterns might supports the view, that no transition of serous borderline tumors into invasive carcinomas occurs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:11:11