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Titolo:
Validation in the canine model of a new non-invasive method of measuring coronary blood flow reserve: Split dose thallium-201 rest/stress imaging
Autore:
Diamond, JA; Machac, J; Vallabhajosula, S; Henzlova, MJ; Ali, MK; Mezrow, CK; Gandses, A; Travis, A; Phillips, RA;
Indirizzi:
Mt Sinai Med Ctr, Cardiovasc Inst, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 ovasc Inst, New York, NY 10029 USA Mt Sinai Med Ctr, Div Nucl Med, Dept Med & Radiol, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 d & Radiol, New York, NY 10029 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIAC IMAGING
fascicolo: 2, volume: 17, anno: 2001,
pagine: 145 - 152
SICI:
0167-9899(200104)17:2<145:VITCMO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOCARDIAL PERFUSION; VASODILATOR RESERVE; ARTERY DISEASE; N-13 AMMONIA; HYPERTENSIVE PATIENTS; EXTERNAL DETECTORS; TOMOGRAPHY; STENOSIS; ANGINA; RUBIDIUM-82;
Keywords:
coronary flow reserve; microspheres; radionuclide imaging; thallium-201;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Diamond, JA Mt Sinai Med Ctr, Cardiovasc Inst, POB 1030,1 Gustave L Levy Pl, New York,NY 10029 USA Mt Sinai Med Ctr POB 1030,1 Gustave L Levy Pl New York NY USA 10029
Citazione:
J.A. Diamond et al., "Validation in the canine model of a new non-invasive method of measuring coronary blood flow reserve: Split dose thallium-201 rest/stress imaging", INT J CAR I, 17(2), 2001, pp. 145-152

Abstract

Diffusely impaired coronary blood flow reserve is difficult to measure non-invasively. We developed and tested a quantitative non-invasive method of measuring coronary blood flow reserve using thallium-201 perfusion imaging. Ten anesthetized dogs were injected simultaneously at rest with thallium-201 and either Ru-103 or Sn-113 microspheres. SPECT images were obtained followed by varying doses of intravenous adenosine, and a second thallium-201 dose was injected simultaneously with either Nb-95 or Sc-46 microspheres. SPECT images were then repeated. The heart was removed, sectioned and counted, along with arterial blood samples. Blood flow was calculated at rest andstress. Peak resting counts in four regions in each of three SPECT slices were subtracted from stress values and stress/rest thallium-201 count ratios (coronary flow reserve (CFR)) were calculated and correlated with the corresponding microsphere flow ratios. Overall correlation of the imaging and microsphere flow ratios was 0.77 (p = 0.0001). Regional correlation coefficients ranged from 0.65-0.86 (p = 0.0001). Coronary blood flow reserve ratios by the microsphere method ranged from 0.7 to 5.3, and by thallium-201 imaging from 0.33-2.45. The non-invasively measured coronary blood flow reserve with thallium-201 imaging and adenosine stress correlates well with microsphere-measured coronary blood flow reserve over a wide range of coronary flows, and should be useful in clinical studies of CFR impairment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:23:05