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Titolo:
IN-VIVO IN-VITRO COMPARISON OF RAT ABDOMINAL-AORTA WALL VISCOSITY - INFLUENCE OF ENDOTHELIAL FUNCTION
Autore:
BOUTOUYRIE P; BEZIE Y; LACOLLEY P; CHALLANDE P; CHAMIOTCLERC P; BENETOS A; DELAFAVERIE JFR; SAFAR M; LAURENT S;
Indirizzi:
HOP BROUSSAIS,SERV PHARMACOL,DEPT PHARMACOL,96 RUE DIDOT F-75674 PARIS FRANCE HOP BROUSSAIS,SERV PHARMACOL,DEPT PHARMACOL F-75674 PARIS FRANCE HOP BROUSSAIS,DEPT MED INTERNE F-75674 PARIS FRANCE INSERM U337 PARIS FRANCE URA CNRS 879 ST CYR LECOLE FRANCE
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 7, volume: 17, anno: 1997,
pagine: 1346 - 1355
SICI:
1079-5642(1997)17:7<1346:IICORA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; ARTERIAL; RELEASE;
Keywords:
VISCOSITY; ENDOTHELIUM; ARTERIAL; COMPLIANCE; AORTA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
P. Boutouyrie et al., "IN-VIVO IN-VITRO COMPARISON OF RAT ABDOMINAL-AORTA WALL VISCOSITY - INFLUENCE OF ENDOTHELIAL FUNCTION", Arteriosclerosis, thrombosis, and vascular biology, 17(7), 1997, pp. 1346-1355

Abstract

Arterial wall viscosity (AWV) is a potential source of energy dissipation in circulation. That arteries, which are known to be markedly viscous in vitro, have lower viscosity in vivo has been suggested but notdemonstrated under similar pressure conditions. Endothelium, which may modulate AWV through smooth muscle tone, could contribute to the lowlevel of viscosity in vivo. Our objectives were first to compare AWV of the rat abdominal aorta, in vivo and In vitro, with similar pulse-pressure waves, and second, to determine whether endothelial function influences AWV in vivo and in vitro. The diameter of the abdominal aorta and distending pressure were measured in vivo and in vitro with a high-resolution echotracking system and a micromanometer, respectively. AWV was calculated as the area of the pressure-volume curve hysteresis. After in vivo examination, the arterial segments were isolated in vitro and submitted to resynthesized pressure waves identical to those recorded in vivo. Deendothelialization was performed in vivo by balloonrubbing; then arteries were examined either in vivo or in vitro. AWV was markedly lower in vivo than in vitro (6.6 +/- 0.7 versus 22.7 +/- 3.7 J . m(-1) . 10(-5), respectively; P<.001). After deendothelialization, a sustained 40% increased AMV was observed during a 15-minute follow-up (P<.01). In vitro, deendothelialized arteries have a 64% higherAWV than segments with endothelium (P<.01). Our results indicate thatthe physiological effective viscosity, measured in vivo in intact animals, is threefold lower than the intrinsic viscosity of the arterial wall, measured in vitro. Endothelium removal determines a sustained increase in AWV, either in vivo or in vitro. These results suggest that active mechanisms compensate for intrinsic viscosity under physiological conditions. One of these energy-saving mechanisms might be dependent on normal endothelial function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:09:35