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Titolo:
RELATION OF PLAQUE LIPID-COMPOSITION AND MORPHOLOGY TO THE STABILITY OF HUMAN AORTIC PLAQUES
Autore:
FELTON CV; CROOK D; DAVIES MJ; OLIVER MF;
Indirizzi:
UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,NATL HEART & LUNG INST,WYNN DEPT METAB MED LONDON NW8 9SQ ENGLAND UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,NATL HEART & LUNG INST,DEPT CARDIAC MED LONDON NW8 9SQ ENGLAND ST GEORGE HOSP,SCH MED,CARDIOVASC PATHOL UNIT,BRITISH HEART FDN LONDON ENGLAND
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 7, volume: 17, anno: 1997,
pagine: 1337 - 1345
SICI:
1079-5642(1997)17:7<1337:ROPLAM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ATHEROSCLEROTIC PLAQUES; ACUTE MYOCARDIAL-INFARCTION; HUMAN MONOCYTE-MACROPHAGES; LOW-DENSITY LIPOPROTEINS; ACUTE CORONARY SYNDROMES; MATRIX METALLOPROTEINASES; INSITU HYBRIDIZATION; UNSTABLE ANGINA; GENE-EXPRESSION; ISCHEMIC DEATH;
Keywords:
PLAQUE DISRUPTION; LIPIDS; FATTY ACIDS; ATHEROSCLEROSIS; THROMBOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
C.V. Felton et al., "RELATION OF PLAQUE LIPID-COMPOSITION AND MORPHOLOGY TO THE STABILITY OF HUMAN AORTIC PLAQUES", Arteriosclerosis, thrombosis, and vascular biology, 17(7), 1997, pp. 1337-1345

Abstract

The propensity of atherosclerotic plaques to disrupt may be influenced by their lipid content and the distribution of these lipids within the plaque. To investigate this, we analyzed the morphological and lipid profiles of 668 human aortic plaques from 30 males who had died of ischemic heart disease. Plaques were classified as disrupted or as intact types A or B, the latter distinction being based on the absence or presence, respectively, of disrupted plaques within the same aorta. Disrupted plaques have a greater content of lipid (P<.001) and macrophages (P<.001) as well as a thinner cap (P<.001) than intact plaques. Lipid concentrations are positively associated with macrophage accumulation in all plaque types and are negatively associated with minimum cap thickness at the edge of disrupted plaques (P<.05). Free cholesterol concentration is inversely associated with minimum cap thickness at thecenter of type B plaques only (P<.05). At the center of intact type Aand B and disrupted plaques, the free-to-esterified cholesterol ratios were 0.9 (range, 0.0 to 2.7), 0.8 (0.0 to 3.9), and 1.6 (0.2 to 4.0), respectively. Esterified cholesterol concentrations were higher at the center of type B plaques, and those of free cholesterol were higherat the center of disrupted plaques. At the edge of disrupted plaques,the free-to-esterified cholesterol ratio was 0.5 (0.0 to 2.7) becauseof the accumulation of esterified cholesterol. Concentrations of all fatty acids were increased at the edge of disrupted plaques compared with the center, but as a proportion of total fatty acids, omega6-polyunsaturated fatty acids (PUFAs) were lower (44% versus 46%, P<.01), possibly reflecting oxidation of PUFAs. These data demonstrate differences in lipid composition and intraplaque lipid distribution between intact and disrupted plaques. At the edge of advanced plaques, increased esterified lipid concentrations, inversely associated with cap thickness, may reflect macrophage activity and a predisposition to rupture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 11:44:00