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Titolo:
Epigenetic and experimental modifications in early mammalian development: Part II - Cytoplasmic transfer in assisted reproduction
Autore:
Barritt, JA; Willadsen, S; Brenner, C; Cohen, J;
Indirizzi:
Inst Reprod Med & Sci St Barnabas, Gamete & Embryo Res Lab, W Orange, NJ 07052 USA Inst Reprod Med & Sci St Barnabas W Orange NJ USA 07052 nge, NJ 07052 USA
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 428 - 435
SICI:
1355-4786(200107/08)7:4<428:EAEMIE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL-DNA; HUMAN OOCYTES; CONTROL REGION; MOUSE EMBRYOS; CRYOPRESERVATION; HETEROPLASMY; ZYGOTES; EGGS; MICE; FERTILIZATION;
Keywords:
cytoplasmic transfer; human oocytes and embryos; human reproduction; IVF; ooplasm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Barritt, JA Inst Reprod Med & Sci St Barnabas, Gamete & Embryo Res Lab, W Orange, NJ 07052 USA Inst Reprod Med & Sci St Barnabas W Orange NJ USA 07052 2 USA
Citazione:
J.A. Barritt et al., "Epigenetic and experimental modifications in early mammalian development: Part II - Cytoplasmic transfer in assisted reproduction", HUM REP UPD, 7(4), 2001, pp. 428-435

Abstract

This report details the use of cytoplasmic transfer in human oocytes, The introduction of a small amount of ooplasm from a donor oocyte or zygote mayalter the function of oocytes, with probable deficiencies. Cytoplasmic transfer from fertile donor oocytes or zygotes into compromised oocytes from patients with recurrent implantation failure after assisted reproduction hasnow led to the birth of nearly 30 healthy babies worldwide. Transfer of small amounts of cytoplasm probably involves mRNAs, proteins and mitochondria, as well as other factors and organelles. Even though the use of cytoplasmic transfer has been employed in several IVF clinics-and pregnancies have resulted-it is not known definitively whether the physiology of the early embryo is affected. This review outlines the experimental cytoplasmic transfer techniques and postulates the future impact in assisted reproduction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:36:42