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Titolo:
Epigenetic and experimental modifications in early mammalian development: Part II - Culture of preimplantation embryos and its long-term effects on gene expression and phenotype
Autore:
Khosla, S; Dean, W; Reik, W; Feil, R;
Indirizzi:
Inst Mol Genet, CNRS, UMR 5535, F-34293 Montpellier 5, France Inst Mol Genet Montpellier France 5 5535, F-34293 Montpellier 5, France Babraham Inst, Programme Dev Genet, Cambridge CB2 4AT, England Babraham Inst Cambridge England CB2 4AT enet, Cambridge CB2 4AT, England
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 419 - 427
SICI:
1355-4786(200107/08)7:4<419:EAEMIE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACYTOPLASMIC SPERM INJECTION; BECKWITH-WIEDEMANN-SYNDROME; IN-VITRO FERTILIZATION; ASSISTED REPRODUCTIVE TECHNOLOGY; NUCLEAR TRANSFER; DNA-METHYLATION; MOUSE EMBRYOS; FETAL DEVELOPMENT; BOVINE EMBRYOS; OVINE EMBRYOS;
Keywords:
assisted reproduction; embryo culture; epigenetic; imprinting; large offspring syndrome;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Feil, R Inst Mol Genet, CNRS, UMR 5535, 1919 Route Mende, F-34293 Montpellier 5, France Inst Mol Genet 1919 Route Mende Montpellier France 5 er 5, France
Citazione:
S. Khosla et al., "Epigenetic and experimental modifications in early mammalian development: Part II - Culture of preimplantation embryos and its long-term effects on gene expression and phenotype", HUM REP UPD, 7(4), 2001, pp. 419-427

Abstract

A growing number of medical, scientific and biotechnological procedures rely on culture of mammalian preimplantation embryos. This review presents currently available data on aberrant offspring development that sometimes arises from commonly applied in-vitro procedures in humans, ruminant species and mice. Comparison between mammalian species reveals similarities in the phenotypic abnormalities that are observed at fetal and perinatal stages of development. In particular, aberrant effects on fetal growth have been observed in multiple studies in which serum complemented the preimplantation culture medium. Although it remains to be determined whether there is a common causal mechanism(s) involved, several hypotheses have been put forward toaccount for the variety of the observed developmental abnormalities. One of these postulates that culture can result in the epigenetic deregulation of developmentally important genes, and that such epigenetic alterations would affect in particular the expression of genes that are subject to genomicimprinting. Imprinted genes play key roles in the control of fetal growth,and altered imprinting can cause growth defects. Some recent in-vitro culture studies on mice and ruminant species now lend support to this hypothesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:43:05