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Titolo:
Cryopreservation of testicular tissue in young cancer patients
Autore:
Hovatta, O;
Indirizzi:
Karolinska Inst, Huddinge Hosp, Dept Obstet & Gynaecol, S-14186 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14186 naecol, S-14186 Huddinge, Sweden
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 378 - 383
SICI:
1355-4786(200107/08)7:4<378:COTTIY>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACYTOPLASMIC SPERM INJECTION; SPERMATOGONIAL STEM-CELLS; HUMAN OVARIAN TISSUE; GERM-CELLS; NONOBSTRUCTIVE AZOOSPERMIA; MOUSE TESTES; ORGAN-CULTURE; IN-VITRO; SPERMATOZOA; TRANSPLANTATION;
Keywords:
cancer; cryopreservation; infertility; testis; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Hovatta, O Karolinska Inst, Huddinge Hosp, Dept Obstet & Gynaecol, S-14186Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14186 4186 Huddinge, Sweden
Citazione:
O. Hovatta, "Cryopreservation of testicular tissue in young cancer patients", HUM REP UPD, 7(4), 2001, pp. 378-383

Abstract

Cryopreservation of testicular tissue might benefit prepubertal boys who must undergo chemotherapy or radiotherapy. Cryopreservation of testicular tissue and testicular cells for intracytoplasmic sperm injection (ICSI) is feasible and widely applied. Testicular tissue from prepubertal boys can alsobe frozen, by applying techniques used with other tissues and with testicular tissue from adult men before ICSI. Good results have been obtained whenpropanediol is used as a cryoprotectant, but glycerol has also been used when freezing testicular tissue, Spermatogonia might also be isolated and cryopreserved as a cell suspension, though practical experience in humans is lacking. Transplantation of the frozen-thawed cells back to the testes after cancer treatment might result in restoration of spermatogenesis. Live offspring have been born to mice after transplantation of fresh, but not cryopreserved, testicular cells. Transplantation is technically feasible also inlarger species, but to date no offspring have been born. Spermatogenesis in vitro would be an excellent option for boys with haematological malignancies who carry a risk of relapse after transplantation; however, at present the method is feasible only for the late stages of spermatogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:29:41