Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Testicular function following chemotherapy
Autore:
Howell, SJ; Shalet, SM;
Indirizzi:
Christie Hosp NHS Trust, Dept Endocrinol, Manchester M20 4BX, Lancs, England Christie Hosp NHS Trust Manchester Lancs England M20 4BX , Lancs, England
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 4, volume: 7, anno: 2001,
pagine: 363 - 369
SICI:
1355-4786(200107/08)7:4<363:TFFC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; TOTAL-BODY IRRADIATION; NON-HODGKINS-LYMPHOMA; LEYDIG-CELL INSUFFICIENCY; GONADAL-FUNCTION; COMBINATION CHEMOTHERAPY; HUMAN SPERM; CYTOTOXIC CHEMOTHERAPY; ENDOCRINE FUNCTION; RADIATION-THERAPY;
Keywords:
chemotherapy; enhancement of spermatogenesis; sperm banking; testicular cancer; testicular function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Shalet, SM Christie Hosp NHS Trust, Dept Endocrinol, Wilmslow Rd, Manchester M20 4BX,Lancs, England Christie Hosp NHS Trust Wilmslow Rd Manchester Lancs England M20 4BX
Citazione:
S.J. Howell e S.M. Shalet, "Testicular function following chemotherapy", HUM REP UPD, 7(4), 2001, pp. 363-369

Abstract

Testicular dysfunction is a common long-term sequela of cytotoxic chemotherapy used in the treatment of many malignancies. The degree to which testicular function is affected is dose- and agent-dependent. The impact on germinal epithelial function of standard multi-agent regimens used in the treatment of lymphomas has been widely studied. Procarbazine-containing regimens result in azoospermia in the vast majority of patients, but much lesser degrees of long-term gonadotoxicity are apparent with the newer forms of chemotherapy. High-dose chemotherapy used as preparation before bone marrow transplant is also associated with irreversible germinal epithelial failure in the majority of men. Treatment of testicular cancer with cisplatin and carboplatin regimens leads to temporary azoo- and oligozoospermia in most men, with a recovery to normospermia in 80% by 5 years. There is also evidence of mild Leydig cell impairment in a proportion of men treated with cytotoxicagents, although the clinical significance of this is not clear. Several methods of preserving testicular function during potentially sterilizing treatment have been considered. At present, sperm banking remains the only proven method, although hormonal manipulation to enhance recovery of spermatogenesis and cryopreservation of testicular germ cells are possibilities for the future.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:24:30