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Titolo:
p27 immunostaining is related to prognosis in malignant mesothelioma
Autore:
Beer, TW; Shepherd, P; Pullinger, NC;
Indirizzi:
Royal Haslar Hosp, Dept Histopathol, Gosport, Hants, England Royal Haslar Hosp Gosport Hants England opathol, Gosport, Hants, England Inst Naval Med, Alvestoke, Hants, England Inst Naval Med Alvestoke Hants England al Med, Alvestoke, Hants, England
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 6, volume: 38, anno: 2001,
pagine: 535 - 541
SICI:
0309-0167(200106)38:6<535:PIIRTP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE INHIBITOR P27(KIP1); PLEURAL MESOTHELIOMA; GASTRIC-CARCINOMA; EXPRESSION; CANCER; SURVIVAL; ADENOCARCINOMA; MANAGEMENT; DISEASE;
Keywords:
malignant mesothelioma; p27; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Beer, TW Royal Perth Hosp, Dept Anat Pathol, GPO Box X2213, Perth, WA 6001, Australia Royal Perth Hosp GPO Box X2213 Perth WA Australia 6001 Australia
Citazione:
T.W. Beer et al., "p27 immunostaining is related to prognosis in malignant mesothelioma", HISTOPATHOL, 38(6), 2001, pp. 535-541

Abstract

Aims: To evaluate the prognostic value of the proliferation-associated antigen p27 in malignant mesothelioma. Methods and results: Sections from 36 patients with malignant mesotheliomawere immunohistochemically stained for the p27 antigen. The results were quantified by recording the proportion of positively stained nuclei and these data were tested for association with patient survival, p27 expression was also compared with tumour type, MIB-1 expression, apoptotic and mitotic indices. Patients with pleural malignant mesothelioma showing low p27 expression (< 53% of cells positive) survived for significantly shorter periods of time than those with high p27 expression (<greater than or equal to> 53% of cells positive) (P = 0.04). The 50% survival time of subjects with low p27 was 4-6 months whereas for those with high p27 expression it was 10-11 months. There was no significant association between p27 expression and MIB-1, apoptotic or mitotic indices. Conclusions: Low p27 expression in pleural malignant mesothelioma is associated with a significantly worse prognosis, p27 appears to be an independent prognostic variable which mag be of value in counselling patients with malignant mesothelioma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:19:24