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Titolo:
DNA variation at the rp49 gene region of Drosophila simulans: Evolutionaryinferences from an unusual haplotype structure
Autore:
Rozas, J; Gullaud, M; Blandin, G; Aguade, M;
Indirizzi:
Univ Barcelona, Fac Biol, Dept Genet, E-08071 Barcelona, Spain Univ Barcelona Barcelona Spain E-08071 t Genet, E-08071 Barcelona, Spain
Titolo Testata:
GENETICS
fascicolo: 3, volume: 158, anno: 2001,
pagine: 1147 - 1155
SICI:
0016-6731(200107)158:3<1147:DVATRG>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR POPULATION-GENETICS; MITOCHONDRIAL-DNA; BACKGROUND SELECTION; NUCLEOTIDE VARIATION; NATURAL-POPULATIONS; SEQUENCE VARIATION; STATISTICAL TESTS; MELANOGASTER; LOCUS; HITCHHIKING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Rozas, J Univ Barcelona, Fac Biol, Dept Genet, Diagonal 645, E-08071 Barcelona, Spain Univ Barcelona Diagonal 645 Barcelona Spain E-08071 elona, Spain
Citazione:
J. Rozas et al., "DNA variation at the rp49 gene region of Drosophila simulans: Evolutionaryinferences from an unusual haplotype structure", GENETICS, 158(3), 2001, pp. 1147-1155

Abstract

An similar to1.3-kb region including the rp49 gene plus its 5 ' and 3 ' flanking regions was sequenced in 24 lines of Drosophila simulans (10 from Spain and 14 from Mozambique). Fifty-four nucleotide and 8 length polymorphisms were detected. All nucleotide polymorphisms were silent: 52 in noncodingregions and 2 at synonymous sites in the coding region. Estimated silent nucleotide diversity was similar in both populations (pi = 0.016, for the total sample). Nucleotide variation revealed an unusual haplotype structure showing a subset of 11 sequences with a single polymorphism. This haplotype was present at intermediate frequencies in both the European and the African samples. The presence of such a major haplotype in a highly recombining region is incompatible with the neutral equilibrium model. This haplotype structure in both a derived and a putatively ancestral population can be mostparsimoniously explained by positive selection. As the rate of recombination in the rp49 region is high, the target of selection should be close to or within the region studied.

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Documento generato il 04/12/20 alle ore 13:30:11